This book reviews biochemistry, molecular biology and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. Surveys cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis.Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

Offers a comprehensive scope ranging from disease initiation to metastasis Focus and emphasis on genetic and cellular mechanisms of prostate cancer Geared toward basic scientists, instead of largely clinically oriented

Autorentext

Scott Dehm is Professor in the Departments of Laboratory Medicine and Pathology and Urology at University of Minnesota. He holds the Apogee Enterprises Chair of Cancer Research at the Masonic Cancer Center, University of Minnesota. He obtained his Ph.D. degree in Biochemistry from the University of Saskatchewan.

Donald Tindall is Professor Emeritus in the Departments of Biochemistry and Molecular Biology and Urology at Mayo Clinic. He obtained his Ph.D. degree from the University of North Carolina at Chapel Hill.

Inhalt
Diet and Lifestyle in Prostate Cancer.- Dietary Carcinogens and DNA Adducts in Prostate Cancer.-Genetic, Environmental, and Nuclear Factors Governing Genomic.- Cells of Origin for Prostate Cancer.- Prostate Cancer Genomic Subtypes.- Prostate Cancer Transcriptomic Subtypes.- Immunological complexity of the prostate cancer microenvironment influences the response to immunotherapy.- The Tumor Microenvironments of Lethal Prostate Cancer.- The Bone Microenvironment in Prostate Cancer Metastasis.- Prostate Cancer Energetics and Biosynthesis.- Canonical and Noncanonical Androgen Metabolism and Activity.- Germline and Somatic Defects in DNA Repair Pathways in Prostate Cancer.- The Role of RB in Prostate Cancer Progression.- Interplay among PI3K/AKT, PTEN/FOXO and AR signaling in prostate cancer.- Androgen Receptor Dependence.- WNT/BETA-CATENIN SIGNALING AND PROSTATE CANCER THERAPY RESISTANCE.- Epigenetic Regulation of Chromatin in Prostate Cancer.- Oncogenic ETS factors in prostate cancer.- Neural Transcription Factors in Disease Progression.- Index.<p