This book provides a comprehensive overview of the management of brain and skull base tumors. It features detailed insight into the intrinsic molecular biology, anatomical foundation, radiological planning, surgical execution, and the novel therapeutics that guide today's treatment regimens. The first section features concepts related to the epidemiology and pathological basis of disease processes, including relevant cellular and molecular biology. In the second section, integral anatomical foundations and principles are covered including microsurgical anatomy of the cerebrum, white matter tracts, ventricles, brainstem, skull base, advancements in radiological imaging, and cognitive examinations. Surgical approaches and how to execute these procedures are then subsequently discussed in the third part of the work.

Principles of Neuro-Oncology: Brain & Skull Base is a practically applicable guide to the latest treatment techniques available to treat these patients. Therefore, it is an indispensable resource for all physicians who utilize these methodologies in their day-to-day practice.

Conveys information through images and videos Discusses current knowledge on molecular biomarkers for decision-making Discusses the most up-to-date therapeutic approcaches including immunotherapy, genetic therapy and new techniques to give intrathecal chemotherapy Includes innovations on surgical techniques as the neurological surgery with robotically operated video optical telescopic microscopy (ROVOT-m)

Autorentext

Dr. Alejandro Monroy Sosa is Neurosurgeon Oncologist and Vascular Neurosurgeon. Assistant Professor, Department of Neurosurgery and Director, Skull Base, Brain & Cerebrovascular Laboratory at Aurora Neuroscience Innovation Institute Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, United States. Assitant Professor, Department of Head and Neck, Instituto Nacional de Cancerología, Mexico City, Mexico.

Training in Vascular Neurosurgery and Skull Base at Arkansas Neuroscience Institute (Prof. Ali Krisht), Vascular Neurosurgery at National Institute of Neurology and Neurosurgery "MVS" (Prof. Nathal), Microsurgical Anatomy at the University of Florida (Prof. Rhoton), Minimally Invasive Neurological Surgery (Endonasal Endoscopic Approach, Port & ROVOT -m) at the Aurora Neuroscience Innovation Institute (Prof. Amin Kassam). Speaker of 120 International and national lectures. Author and coauthor of 44 international and national scientific and author/coauthor of 8 book chapter.

Dr. Srikant S. Chakravarthi is currently a post-doctoral neurosurgical research fellow. Dr. Chakravarthi completed his undergraduate education at the University of Windsor in Biological Sciences with Honors, followed by a Master of Science in Interdisciplinary Biomedical Sciences/Oncology at the State University of New York at Buffalo/Roswell Park Cancer Institute. He then completed his medical training at the Universidad Autonoma de Guadalajara and New York Medical College with distinction. Apart from completing multiple research and clinical endeavors, including one at the University of Alberta under Dr. Keith Aronyk, Dr. Chakravarthi most recently completed his research fellowship training under Dr. Amin Kassam, in skull base, oncology, and neuroradiology, at Aurora St. Luke's Medical Center and was the Director of the Neuroanatomy and Neuroradiology Laboratory at Aurora Research Institute. He has either authored or coauthored over 20 scientific publications, over 25 book chapters, and has given numerous presentations in national and international conferences.

Jaime G. de la Garza Salazaris a medical oncologist. He is currently a clinical researcher of the National Cancer Institute - Mexico. Member of the National System of Researchers level II. Member of the European Society of Medical Oncology. He is the author of more than 180 national and international scientific papers. Speaker of than more 1000 international and national lectures. Editor of 7 books. author and coauthor of 9 book chapter. Distinguished achievement award American society of clinical oncology (ASCO) Chicago, Ill. Editor Journal of Cancerology.

Dr. Abelardo Meneses García. is an Oncologist Pathologist. He is currently General Director of the National Cancer institute Mexico. He is a Member of theNational System of Researchers level II and a member of the South West Oncology Group He has authored and co-authored more than 140 national and international scientific papers and is the Editor of 9 books. Author and coauthor of 20 book chapter.

Dr. Amin B. Kassam is a Neurosurgeon. He is currently the founder and CEO of Neeka Health Enterprises, LLC. Over the past two decades, Dr. Kassam has been either the Chairman or Director of four separate Neurosurgery programs, including University of Pittsburgh, University of Ottawa, and more recently, Aurora St. Luke's Medical Center; created and globally scaled three disruptive novel surgical procedures, including the development and application of the expanded endonasal approach (EEA); founded or held leadership roles in four separate technology start-up companies constructed for the purpose of creating the underlying platforms for these procedural innovations; and, has held executive health care administration leadership roles needed to translate these innovations through tech-enabled services. Dr. Kassam has published over 300 peer-reviewed articles, given over 250 lectures globally and served as a distinguished guest for multiple international meetings and societies.

Inhalt

1. Introduction.- Part 1: Tumor Biology .- 2. Epidemiology.- 3. Molecular Biomarkers in Tumors.- 4. Molecular Biomarkers in Brain Metastasis.- 5. Pathology Classification.- Part 2: Planning .- 6. Microsurgical Anatomy of the Cranial Base and the White Matter Tracts (3D).- 7. Microsurgical Anatomy of the Brainstem.- 8. Advances in Neuroimaging.- 9. DTI: planning for skull base and intra-axial tumors approaches.- 10. Neurological Examination.- 11. Neuro-Psychiatric Examination.- 12. Embolization of the Cranial Base Tumors.- Part 3:RT.- 13. Whole Brain Radiation.- 14. Radiosurgery (LINAC).- Part 4: Chemotherapy .- 15. Chemotherapy.- 16. Intratumoral Chemotehrapy.- 17. Genetic Therapy ( Gliomas).- Part 5: Surgery.- 18. Surgical Radial Corridors Dorsal and Ventral Approaches to the Cranial Base).- 19. Parafascicular Surgery (Chassis).- 20. Craniofacial Approaches.- 21. Early experience with the ROVOT-m in Neurosurgery.- 22. Awake Surgery in Brain Tumors.- 23. Transclival Approaches.- 24. Surgery in Spine Tumor.- 25. Infratemporal Fossa and Pharapharyngeal Space Surgery.- 26. 360 around of the Craniocervical Junction.- 27. Neuroendoscopy.- 28. 360 around of the Orbit.- Part 6: Tumors .- 29. Surgery in Gliomas.- 30. Surgery in Meningiomas of the Anterior Cranial Base (EEA).- 31. Surgery in Meningiomas of the Anterior Cranial Base (Open).- 32. Surgery in Meningiomas of the Middle Cranial Base.- 33. Surgery in Meningiomas of the Posterior Cranial Base.- 34. Surgery in CPA angle.- 35. Surgery for Craniopharyngioma.- 36. Pituitary Surgery (EEA and Open).- 37. Yugular Schawannomas Surgery.- 38. Surgery of the Intraventricular Tumors.- 39. Brain Metastasis Surgery.- 40. Surgery of Esthesioneuroblastoma.- 41. Chordomas Surgery.- 42. Brainstem Surgery.