Precision Medicine in Interstitial Lung Disease

This book provides a state-of-the-art update on precision medicine in Interstitial Lung Diseases (ILD). This is a rapidly evolving and growing field. There have been multiple recent manuscripts and reviews on this topic although each of these only includes certain aspects of precision medicine in ILD, broken down in different ways. It is thus the aim of this book to aggregate this information into a single volume.

The first chapter broadly defines precision medicine. This introduces and defines various areas of precision medicine to set the reader up for understanding what is discussed at a higher level for the remainder of the book. The chapter ends with a glossary of relevant terms for quick reference while readers work through the remainder of the book. The second chapter highlights successes and obstacles in using and implementing precision medicine in other lung diseases such as cystic fibrosis and lung cancer.

The next section focuses on how information that is currently available can be thought of as contributing to precision medicine. For instance, how a provider might think of and weigh peripheral monocytosis on a CBC, how race and ethnicity might influence diagnosis and prognosis, and how environmental influences such as air pollution or occupational exposures may interact with genetics leading to increased risk for disease and/or poor outcomes in ILD. One chapter in this section discusses using precision medicine for screening family members for ILD and how knowing results of a patient's family member's testing or their clinical course may or may not be useful. Additionally, authors explore how technology is contributing to and influencing ILD diagnosis and treatment. This includes machine learning and AI, particularly in radiology, big data, and more specific patient reported outcomes gathered via apps and devices.

Finally, expert authors highlight the importance of considering economics and equity in precision medicine as some of the above approaches are at this point quite costly to develop and employ and look to what future developments and research are on the horizon.

This is an ideal guide for practicing pulmonary and critical care physicians, those with expertise in interstitial lung diseases as well as general pulmonologists.

Provides a state-of-the-art view of precision medicine concepts and techniques for interstitial lung diseases Includes a chapter defining and describing precision medicine to put the remainder of the book in context for the reader Includes chapters focused on biologic and genetic markers, as well as on technology and machine learning

Autorentext

Dr. Collins completed fellowships in Pulmonary and Critical Care Medicine and Interstitial Lung Diseases at University of Washington Medical Center in Seattle, WA. Dr. Collins' clinical practice has focused on patients with Interstitial Lung Diseases. She has published on topics ranging from hypersensitivity pneumonitis to sarcoidosis and was a committee member for the diagnosis of hypersensitivity pneumonitis clinical practice guidelines. She is currently working at EvergreenHealth Pulmonary Care in Kirkland, WA and is a Clinical Associate Professor at the University of Washington Medical Center.
Dr. Montesi completed her fellowship training in Pulmonary and Critical Care Medicine though the Harvard Combined Program in Boston, MA. She is currently a faculty member in the Division of Pulmonary and Critical Care Medicine at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School in Boston, MA. Her clinical expertise is in Interstitial Lung Diseases. Her research focuses on applying advanced imaging techniques to pulmonary fibrosis. She has over 50 peer reviewed publications in the area of ILD.

Inhalt

Introduction: Precision Medicine in Interstitial Lung Disease.- Lessons Learned from Precision Medicine in Other Lung Diseases.- All in the Family: Role for Precision Medicine in Screening and Disease Course Prediction.- Genetic Biomarkers for Interstitial Lung Disease.- MOLECOLAR BIOMARKERS IN INTERSTITIAL LUNG DISEASES.- Bronchoscopy in Precision Diagnosis of Interstitial Lung Disease.- Environmental Influences on ILD Development and Clinical Course.- Influence of Race and Ethnicity on the Precision Diagnosis and Treatment of ILD.- In the Air: Exhaled Breath Analysis and Airway-Based Biomarkers in Interstitial Lung Diseases.- Animal and Translational Models for Precision Medicine in ILD.- Big Data: Pearls and Pitfalls for Precision Medicine in Interstitial Lung Disease.- The Future of Precision Medicine in Interstitial Lung Disease.