Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.

Includes supplementary material: sn.pub/extras

Zusammenfassung
Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells.

Inhalt
I: Platinum Chemistry.- 1 The Chemistry of Cisplatin in Aqueous Solution.- 2 Chemistry and Structural Biology of 1,2-Interstrand Adducts of Cisplatin.- 3 Transplatin-Modified Oligonucleotides as Potential Antitumor Drugs.- II: Platinum Biochemistry.- 4 Cisplatin Accumulation.- 5 Cisplatin Resistance in Ovarian Cancer: Mismatch Repairand Engagement of Apoptosis.- 6 DNA Adduct Tolerance and Bypass.- 7 How Does Cisplatin Kill Cells?.- III: Clinical Antitumor Activity and Toxicology of Platinum Drugs.- 8 Clinical Experience with Cisplatin and Carboplatin.- 9 Clinical Experience: Platinum and Taxanes.- 10 Clinical Experience: DACH-Based Platinum Drugs.- 11 Clinical Toxicology of Platinum-Based Cancer Chemotherapeutic Agents.- 12 Toxicology and Regulatory Aspects of Platinum Drugs.- IV: New Platinum Drugs of the Future.- 13 New Platinum Drugs: The Pathway to Oral Therapy.- 14 Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents: Toward a New Paradigm.