In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

Provides a comprehensive review of recent developments made in the basic science and the exciting new therapeutic strategies of the PI3K-mTOR pathway-related signal transduction Examines the contribution of the PI3K-AKT-mTOR signaling pathway towards the development and the progression of human tumors Includes two complementary sections which address the problem of etiology and disease progression? Includes supplementary material: sn.pub/extras

Autorentext
Nandini Dey, M.S., Ph.D., is a Senior Scientist Head of Cancer Biology, Avera Cancer Institute Center for Precision Oncology. She is also Assistant Professor of the Department of Internal Medicine at The University of South Dakota Sanford School of Medicine. Dey has more than 20 years of experience in translational research and has authored or co-authored more than 80 publications.< Pradip De, M.S., Ph.D., is a Senior Scientist Head of Translational Oncology, Avera Cancer Institute Center for Precision Oncology. He is also Assistant Professor of the Department of Internal Medicine at The University of South Dakota Sanford School of Medicine. De has more than 20 years of experience in translational research in academics and industry and has authored or co-authored more than 90 publications. Brian Leyland-Jones, MB BS, Ph.D. is Vice President of Avera Cancer Institute Center for Precision Oncology. Dr. Leyland-Jones is a consulting professor at the Stanford University School of Medicine. He is an internationally renowned breast cancer expert with more than 35 years experience in patient care and research, has published over 170 papers and has received over 11,000 citations in his scientific career.

Inhalt
PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics.- Part 1: PI3K-mTOR Pathway in Cancers.- The mTOR Complexes in Cancer Cell Metabolism.- PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breast Cancers and Beyond.- The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures.- Resistance to PI3K Pathway Inhibition.- Part 2: PI3K-mTOR Pathway in Cancer Medicine.- Combination Therapies Targeting the PI3K/AKT/mTOR Pathways.- Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma.- HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies.- The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities.