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Pharmacogenomics in Drug Discovery and Development

  • Fester Einband
  • 504 Seiten
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Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmac... Weiterlesen
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Beschreibung

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.

Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.



Examines both fundamental concepts and advanced technologies in pharmacogenomics

Uses cutting-edge technologies to pursue systems-based pharmacogenomics, including bioinformatics, microarray, and association studies

Methodical, state-of-the-art contributions covering topics from individual molecules, gene-drug interactions, to systemic diseases presented by leading experts

Explores extensive applications of pharmacogenomics in drug development for diseases including psychiatric disorders, cardiovascular diseases, cancer, Alzheimer's disease, rheumatoid arthritis, asthma, and infectious diseases



Inhalt
Table of Contents 1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery Qing Yan 2. Applications of Microarrays and Biochips in Pharmacogenomics Gary Hardiman 3. Confounding in Genetic Association Studies and Its Solutions Donglei Hu and Elad Ziv 4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg 5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy Tessa M. Bosch 6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease Miles D. Thompson, David E.C. Cole and Pedro A. Jose 7. G Protein-coupled Receptors Disrupted in Human Genetic Disease Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole 8. G Protein-coupled Receptor Pharmacogenetics Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole 9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders Hamid Mostafavi Abdolmaleky and Sam Thiagalingam 10. Pharmacogenomics in Alzheimer's Disease Ramón Cacabelos 11. Pharmacogenetics of Asthma Gregory A. Hawkins and Stephen P. Peters 12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics Sharon Cresci 13. Pharmacogenomics in Gastrointestinal Disorders Michael Camilleri and Yuri A. Saito 14. Pharmacogenomics in Rheumatoid Arthritis Prabha Ranganathan 15. Cancer Pharmacogenetics Sharon Marsh 16. Pharmacogenomics in the Preclinical Development ofVaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology Karin J. Regnström 17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines Lennart J. Nilsson and Karin J. Regnström

Produktinformationen

Titel: Pharmacogenomics in Drug Discovery and Development
Editor:
EAN: 9781588298874
ISBN: 1588298876
Format: Fester Einband
Herausgeber: Humana Press
Genre: Medizin
Anzahl Seiten: 504
Gewicht: 916g
Größe: H241mm x B160mm x T31mm
Jahr: 2008
Auflage: 2008

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