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Pertussis Infection and Vaccines

  • Kartonierter Einband
  • 180 Seiten
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This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution t... Weiterlesen
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Beschreibung

This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.

Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.

This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.



Offers a comprehensive overview of the research on pertussis infection and vaccination

Discusses pertussis prevention, control and clinical management

Highlights the latest vaccination strategies and novel vaccines



Autorentext

Dr. Giorgio Fedele

Istituto Superiore di Sanità

Roma, Italy

Email : giorgio.fedele@iss.it

Dr. Clara Maria Ausiello

Roma, Italy

Email : clara.ausiello@gmail.com



Zusammenfassung

"The audience would most appropriately include individuals interested in microbiology, immunology, vaccinology, infectious disease, or public health. Readers who would benefit most would be at the graduate or professional level. ... it would be a good starting point for a wide variety of learners." (Kari Neemann, Doody's Book Reviews, February 26, 2021)



Inhalt


1. Evolution of the genus BordetellaeCorresponding author: Andrew Preston Email : A.Preston@bath.ac.uk
2. Molecular epidemiology of B. pertussis Corresponding author: Qiushui He Email : qiuhe@utu.fi 3. Role of major virulence factors in pertussis infection and disease pathogenesis Corresponding author: Nick Carbonetti Email : ncarbonetti@som.umaryland.edu
4. Functional programming of innate immune cells in response to B. pertussis infection and vaccination Corresponding author: Dimitri Diavatopoulos Email : Dimitri.Diavatopoulos@radboudumc.nl
5. Superior imprinting of B. pertussis specific CD4+ T cell immunity by natural infectionCorresponding author: Cecile ACM van Els Email : cecile.van.els@rivm.nl
6. Human immune responses to pertussis vaccinesCorresponding author: Giorgio Fedele Email : giorgio.fedele@iss.it
7. Pertussis: diagnosis, prevention and control Corresponding author: Paola Stefanelli Email : paola.stefanelli@iss.it
8. Pertussis on low- and middle-income countries (LMIC): a pragmatic approach Corresponding author: Nicole Guiso Email : nicole.guiso@pasteur.fr
9. Clinical findings and management of pertussis Corresponding author: Susanna Esposito Email : susanna.esposito@unipg.it
10. Need for improved immunization strategies. Corresponding author: Antonio Cassone Email : antonio.cassone2@gmail.com
11. New pertussis vaccines: a need and a challenge. Corresponding author: Daniela Hozbor Email : hozbor.daniela@gmail.com

Produktinformationen

Titel: Pertussis Infection and Vaccines
Untertitel: Advances in Microbiology, Infectious Diseases and Public Health Volume 12
Editor:
EAN: 9783030332518
ISBN: 3030332519
Format: Kartonierter Einband
Herausgeber: Springer International Publishing
Genre: Medizin
Anzahl Seiten: 180
Gewicht: 351g
Größe: H254mm x B178mm x T9mm
Jahr: 2021
Untertitel: Englisch
Auflage: 1st ed. 2019

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