This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer's Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Discusses each type of perinatal tissue-derived stem cells, their characteristics and capabilities Comprehensive coverage of all aspects of perinatal tissue-derived stem cells from experimental and pre-clinical through clinical, ethical considerations and more Includes useful topics like guidance for clinical-grade and GMP-compliant manufacturing Includes supplementary material: sn.pub/extras

Autorentext

Dr. Babak Arjmand received his M.D. from Iran University of Medical Sciences, and Ph.D. from Tehran University of Medical Sciences, Tehran, Iran. He is currently vice chancellor for research at Metabolic Disorders Research Center, Endocrinology and Metabolism Cellular-Molecular Sciences Institute in Tehran, Iran. His research focuses on the stem cell translation from the basic to the clinic and GMP-compliant manufacturing for cellular therapy. Dr. Arjmand is member of different cell and tissue committees and groups such as National Committee of Tissue, Cell and Gene Therapy at Iran Food and Drug Organization (MOH), Iranian Council of Stem Cell Technologies, National Working Group for providing National Guideline on Stem Cell therapy, etc.

Inhalt
Preface.- 1.Functional Dualism of Perinatal Stem Cells.- 2.Immunomodulatory Properties of Perinatal Tissue-Derived Stem Cells.- 3.Umbilical Cord Tissue and Wharton's Jelly Mesenchymal Stem Cells Properties and Therapeutic Potential.- 4.Perinatal Tissues-Derived Endothelial Progenitor Cells.- 5.Human Amniotic Membrane as a Biological Source for Regenerative Medicine.- 6.Current Understanding Realities of Umbilical Cord Stem Cells Biology and Future Perspectives in Clinical Application.- 7.Characteristics of Mesenchymal Stem Cells Derived from Amniotic Membrane: A Potential Candidate for Stem Cell based Therapy.- 8.Amniotic Fluid: A Source of stem cells for therapeutic use and modeling of Human Genetic Diseases.- 9.cGMP-Compliant Perinatal Stem Cells.- 10.cGMP facility for clinical grade cell manufacturing: a brief review of requirements and design considerations.- 11.Ethical Issues in Perinatal Tissue Derivation and Regenerative Medicine.