The Proceedings of the Fifth International Pediatric Nephrology Symposia are dedicated to those who make the writing possible: the delegates; those who wanted to attend, but could not, and to our colleagues, families and friends who helped organize the meeting. with the advent of certification of pediatric nephrologists in the USA and the increasing numbers of pediatric nephrologists contributing to and practic ing this specialty throughout the world, it is appropriate that we begin to record our international symposia in order to periodically document the State of the Art of pediatric nephrology and to share new information in a timely fashion with colleagues who care for children. Four previous international pediatric nephrology symposia have been spon sored by the International Pediatric Nephrology Association. These meetings were held in Guadalajara, Mexico, 1968, Paris, France, 1971, Washington, DC, USA, 1974 and Helsinki, Finalnd, 1977. This is the first time that it has been possible to organize the publication of the proceedings of a symposium. The enclosed manuscripts represent more than seventy percent of the symposia presentations delivered at the Fifth International Pediatric Symposia (October 6-10, 1980, Phila., PAl which was - hosted by St. Christopher's Hospital for Children and The Children's Hospital of Philadelphia representing the Departments of Pediatrics of Temple University School of Medicine and The University of Pennsylvania School of Medicine.

Inhalt
I. State of the Art Presentations.- Current Problems in the Pathogenesis of Glomerulonephritis.- Developmental Renal Physiology.- Renal Tubular Acidosis.- II. Symposia Presentations.- Mechanisms of Immune Complex Injury.- Cell-Mediated Mechanisms in Renal Disease.- The Use of Isolated Tubules in the Study of Regulation of Cell Volume.- Role of Na Entry in the Regulation of Proliferation of Cultured Fibroblasts:Effect of Vasopressin.- Micropuncture in Developmental Renal Physiology.- The Clinical Features of Chronic Interstitial Nephritis.- Pathology of Interstitial Nephritis.- Henoch-Schönlein Purpura:A Problem or Not.- Membranoproliferative Glomerulonephritis: Classification and Treatment.- Plasma Catecholamines in Normotensive Children with Essential Hypertension.- Uric Acid Regulation in Hypertensive Children.- Renal Vein Renin Determinations in Evaluating Hypertensive Children.- Vesicoureteral Reflux and Urinary Tract Infection:Introduction to Seminar.- Report on the International Vesicoureteral Reflux Study in Children (IRSC).- The Natural History of Vesico-Ureteric Reflux.- Controlled Clinical Trials Introduction.- Clinical Survey of Hepatitis B Antigenemia Associated Nephropathy in Children.- Cyclophosphamide Versus Chlorambucil in the Treatment of Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome.- Anticoagulant Versus no Specific Treatment in Childhood Hemolytic Uremic Syndrome. A Randomized Prospective Study.- Principles and Practices of Controlled Clinical Trials.- Problems of Long Term Dialysis in Children.- Developmental Aspects of Peritoneal Dialysis.- Protein-Energy Requirements of Children and Adolescents on CAPD. Preliminary Results of Nitrogen Balance Studies.- Clinical Aspects of Renal Osteodystrophy.- 1,25-Dihydroxyvitamin D3 in the Treatment of Juvenile Renal Osteodystrophy.- The Spectrum of Skeletal Manifestations in Renal Osteodystrophy.- 25 (OH) D3 in The Treatment of Juvenile Renal Osteodystrophy.- Transitional Nephrology.- Renal Function in Fetal Life.- Adaptation of the Infant to an External Milieu.- Factors Governing the Development of Renal Control of Na Homeostasis.- The Kidney Following Cardiac Surgery.- Sickle Cell Nephropathy.- Cystinosis and the Kidney.- Peritoneal Nutrition in Children Preliminary Results in Renal Failure.- Amino Acid and Protein Metabolism in Chronic Renal Failure.- Energy Metabolism in Chronic Renal Failure.- Lipid Metabolism in Chronic Renal Failure.- Current Issues in Pediatric Renal Pathology: Segmental Hypoplasia and Glomerulocystic Disease.- The Glomerular Morphology of Membranoproliferative Glomerulonephritis (MPGN).- Circulating Immune Complexes and Systemic Lupus Erythematosus.- Focal Glomerulosclerosis A Review.- Ultrasound Evaluation of the Child's Urinary Tract.- Radionuclide Imaging in Pediatric Nephrology:An Update.- Immunologic Considerations in Renal Trnasplantation.- Recurrence of the Original Disease in the Transplanted Kidney.- Hypertension in Children With Kidney Transplants.- The Nature of Amino Acid Transport Disorders.- Amino Acid Transport.- Current Issues in Hydrogen Ion Transport.- The Management of Resistant Hypertension The Role of Minoxidil.- Chlorambucil Therapy in the Nephrotic Syndrome.- Anticoagulant Therpay.- Growth Failure, End Stage Renal Disease and Somatomedin.- An Approach to Study the Role of Prostaglandins.- Points to Remember in Pharmacologie Glucocorticoid Treatment of Nephrotic Syndrome.- Renal Metabolic Alkalosis.- Pathogenesis of Neo-Mull-Soy (Syntex) Alkalosis.- Metabolic Alkalosis From a Chloride Deficient Formula: Renal Histology.- Metabolic Alkalosis, Prostaglandins, Low Chloride or Something Else?.- Uremic Poisoning.- On Going Protocols in End Stage Renal Disease 1. Height Growth Following Renal Transplantation. 2. Zinc Supplementation in Predialysis Patients. 3. Renal Transplants in Children