Autorentext

Stig Pedersen-Bjergaard is Professor at the School of Pharmacy, University of Oslo, Norway and at the Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Denmark. His research is in the area of pharmaceutical analytical chemistry. Bente Gammelgard is Professor of Analytical Biosciences at the University of Copenhagen, Denmark. She is responsible for teaching Instrumental Analytical Chemistry. Trine Grønhaug Halvorsen is Professor at the School of Pharmacy, University of Oslo, Norway.

Klappentext

Primary source for learning pharmaceutical analytical chemistry, fully updated and revised to reflect current practice and Pharmacopoeia standards Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques, and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products, and drug substances in biological fluids. Extensively revised throughout to reflect the current European Pharmacopoeia (Ph.Eur) and United States Pharmacopeia (USP), this Third Edition presents updated methodologies, practical examples, and calculations to reflect current pharmaceutical laboratory practice. Revisions to the chapter structure, text, and figures have been implemented to improve clarity and comprehension. New practice problems, up-to-date practical examples, and detailed illustrations are also included throughout the text. Written by a team of experienced academics, Introduction to Pharmaceutical Analytical Chemistry explores topics including:

• Fundamentals of bases, acids, solubility, polarity, partition, stereochemistry, and pharmaceutical analytical chemistry
• Marketing authorizations, pharmaceutical manufacturing, titration, UV-Vis spectrophotometry, IR spectrophotometry, and atomic spectrometry
• Separation principles in liquid chromatography, high-performance liquid chromatography, gas chromatography, electrophoretic methods, and mass spectrometry
• Sample preparation, quality of analytical data and validation, and chemical analysis of pharmaceutical ingredients and preparations

• Bioanalysis chemical analysis of pharmaceuticals in biological fluids and chemical analysis of biopharmaceuticals Introduction to Pharmaceutical Analytical Chemistry is essential reading for chemists, biochemists, and other scientists entering the pharmaceutical industry, along with undergraduate and graduate students enrolled in pharmaceutical courses.

  Inhalt

  Preface to the Third Edition xiii

  Symbols and Units xv

  Chapter 1: The Link Between Pharmaceuticals and Analytical Chemistry 1

  Chapter 2: The Link between Pharmaceutical Substances and Pharmacopoeias 15

  Chapter 3: Chemical and Physicochemical Properties of Pharmaceutical Substances and Reagents 39

  Chapter 4: Fundamentals of Pharmaceutical Analytical Chemistry 59

  Chapter 5: Titration 97

  Chapter 6: Introduction to Spectroscopic Methods 121

  Chapter 7: UV-Vis Spectrophotometry 130

  Chapter 8: Infrared Spectrophotometry 150

  Chapter 9: Atomic Spectrometry 161

  Chapter 10: Introduction to Chromatography 175

  Chapter 11: Separation Principles in Liquid Chromatography 190

  Chapter 12: High-Performance Liquid Chromatography 215

  Chapter 13: Gas Chromatography 230

  Chapter 14: Electrophoretic Methods 246

  Chapter 15: Mass Spectrometry 262

  Chapter 16: Sample Preparation 290

  Chapter 17: Data Quality, Quantification and Validation 311

  Chapter 18: Chemical Analysis of Pharmaceutical Substances 337

  Chapter 19: Chemical Analysis of Pharmaceutical Products 380

  Chapter 20: Bioanalysis 415 20.1 Biological Fluids: Composition, Sample Collection and Storage 416

  Chapter 21: Chemical Analysis of Biopharmaceuticals 432

  Index 469