Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

A good overview of the current understanding of the molecular events in cancer biology and how they are being exploited for targeting cancer treatments at the molecular level.

Autorentext
Dr Lauren Pecorino obtained her PhD in Cell and Developmental Biology at the State University of New York at Stony Brook, USA. She then moved to London to carry out a post-doctoral tenure at the Ludwig Institute for Cancer Research where she studied the phenomenon of limb regeneration. Here she used a technique called biolistics, using a 'gene gun' to shoot gold bullets coated with DNA to introduce genes into the regenerating limbs of live newts. Since 1996, Lauren has been a member of academic staff at the University of Greenwich, where she developed her interest in teaching Cancer Biology. In 2018, Lauren was made a Principal Fellow of the Higher Education Academy.

Inhalt

• 1: Introduction

• 2: The cancer genome

• 3: Regulation of gene expression

• 4: Growth factor signaling and oncogenes

• 5: The cell cycle

• 6: Tumor suppressor genes

• 7: Apoptosis

• 8: Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias

• 9: Metastasis

• 10: Angiogenesis

• 11: Reprogrammed metabolism and diet

• 12: Tumor immunology and immunotherapy

• 13: Inflammation, infection, and the microbiome

• 14: Strategies and tools for research and drug development