This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.

The 48th Annual Meeting of the International Society on Oxygen Transport to Tissue 2021 proceedings Unique cross-disciplinary work on a range of topics related to oxygen transport Diversified and interesting research reflecting ISOTT's long history of 48 years

Autorentext

Ursula Wolf, PhD is Professor and Director of the Institute of Complementary and Integrative Medicine at the University of Bern in Switzerland. Her research interests focus on integrative medicine, in particular patient centered research, integrative physiology, and clinical studies.

Felix Scholkmann, PhD is a lecturer at the University of Zurich and a Research Associate at the Biomedical Optics Research Laboratory (Dept. of Neonatology) of the University Hospital Zurich, University of Zurich in Switzerland, and at the University of Bern in Switzerland. His research mainly concerns the fields of neurophotonics and biomedical signal processing, as well as integrative neuroscience and physiology. He has authored or co-authored over 140 research papers, book chapters and reviews.

Joseph C. LaManna, PhD is The Jeannette M. and Joseph S. Silber Professor for the Study of Brain Sciences in the Department of Physiology & Biophysics at Case WesternReserve University. He has been a member of ISOTT since 1974 and served as Past President of the Society (2009). He is the Series Editor of the ISOTT Proceedings. He has been involved in cerebrovascular research for 40 years. His research is concerned with brain metabolism, energy and cerebral blood flow, angiogenesis and neurodegeneration. The role of these mechanisms in tissue response to pathological insults (stroke, cardiac arrest and resuscitation, hypoxia) is being actively investigated. His recent research has centered on ketones, cerebral angiogenesis and the role of hypoxia-inducible factor-1 in physiological adaptation to hypoxia, neuroprotection and ischemic preconditioning. He has authored or co-authored over 200 research papers and review chapters.

Inhalt
Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury.- Imaging cerebral energy metabolism in healthy infants.- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women.- Brain Tissue Conductivity in Focal Cerebral Ischemia.- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination.- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients.- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations.- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity.- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen.- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mildtraumatic brain injury.- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice.- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia.- Chronic Ketosis Modulates HIF1-Mediated Inflammatory Response in Rat Brain.- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study.- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS).- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study.- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation.- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation.- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study.- Silent Hypoxemia in COVID-19 pneumonia.- LowFlow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis.- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry.- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients.- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data.- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia.- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study.- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury.- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography.- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study.- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study.- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia.- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS.- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography.- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System.- Improved optical tissue model for tissue oximetry imaging applications.- In vitro validation of a new tissue oximeter using visible light.- Photon and Proton Dose Painting based on Oxygen Distribution Feasibility Study and Tumour Control Probability Assessment.- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells.- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy.- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo.- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours.- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation.- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy.- Optical Redox Imaging Is Responsive to TGF Receptor Signaling in Triple-Negative Breast Cancer Cells.- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression.- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells.- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera.- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier.- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths.- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas.- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH.- Assessment of nicotinamid…