The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage ment.

Klappentext

This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test.

Inhalt

1. Oncogenes and Tumor Suppressor Genes.- 2. Activated Oncogenes and Putative Tumor Suppressor Genes Involved in Human Breast Cancers.- 3. Oncogenes in Human Lung Cancer.- 4. Thyroid Growth Factors and Oncogenes.- 5. Growth Regulation of Human Neuroblastoma.- 6. Kaposi Sarcoma: A Cytokine Responsive Neoplasia?.- 7. BCL-2: Physiology and Role in Neoplasia.- 8. Malignant Transformation by abl and BCR/ABL.- 9. The Biological and Clinical Roles of Increased Insulin Receptors in Human Breast Cancer.- 10. The Role of Fibroblast Growth Factors and Related Oncogenes in Tumor Growth.- 11. Transforming Growth Factor-alpha and its Role in Neoplastic Progression.- 12. Growth Regulation by Transforming Growth Factor-ß.- 13. Signal Transduction by Receptor Tyrosine Kinases.- 14. Involvement of G Proteins, Cytoplasmic Calcium, Phospholipases, Phospholipid-Derived Second Messengers, and Protein Kinases in Signal Transduction from Mitogenic Cell Surface Receptors.- 15. Fos and Jun: Inducible Transcription Factors Regulating Growth of Normal and Transformed Cells.- 16. DNA Binding by the myc Oncoproteins.- 17. Normal and Malignant Growth Control by p53.- 18. Nucleoside Diphosphate Kinases, nm23, and Tumor Metastasis: Possible Biochemical Mechanisms.- 19. Angiogenesis: A Mechanism by Which Oncogenes and Tumor Suppressor Genes Regulate Tumorigenesis.