This book has expanded classic concept of immunology. Immunoglobulins have been widely discovered to be produced by many non-B cells. The non B cell-derived Igs display multifunction, which not only includes antibody activities and cellular biological functions under physiological conditions, but also directly participate in the pathological process of malignant tumour and immune-related diseases. This book provides new perspectives and a solid foundation for medical students, basic and clinical scientists to re-understand and broaden the physiological and pathological significance of Ig.

Comprehensively discussing non B cell-derived immunoglobulins Summarizing the cutting-edge developments of non B cell-derived Ig Introducing the pathological significance of non B-Ig in different diseases

Autorentext
Dr. Xiaoyan Qiu is a professor and director of Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center. Her research focuses on non B cell- derived immunoglobulins and cancer immunotherapy. She has published more than 80 articles on international peer-reviewed journals, such as Cancer Research, Leukemia and Cell Mol Immunol, etc.

Inhalt

Chapter 1 The history of appreciation of immunoglobulin and the discovery of non-B cell derived immunoglobulins.- Chapter 2 Expression profile of non B-Ig in different lineage cells.- Chapter 3 Unique V(D)J recombination characteristics and repertoire of non B-Ig.- Chapter 4 Unique regulation mechanismof non B-Ig gene.- Chapter 5 Unique structure and function of non B-Ig.- Chapter 6 Comparison of non B-Ig and B-Ig.- Chapter 7 Functionsand clinical relevanceof non-B cell derived immunoglobulin in liver.- Chapter 8 Significance of non-Bcell derived immunoglobulins in renal disease.- Chapter 9 Functions and clinical significance of myocardial cell-derived Immunoglobulins.- Chapter 10 Biological functions and clinical significance of intestinal non B-Immunoglobulins.- Chapter 11 Function of IgG and IgA in normal human skin.- Chapter 12 Significance of cancer-derived IgG in lung cancer.- Chapter 13 Significance of cancer-derived IgG in breast cancer.- Chapter 14 Significance of cancer-derived IgG in pancreatic cancer.- Chapter 15 Biological functions and clinical significance of non B-Ig in hemopoietic system.