This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.

Discusses new candidate for rapid-acting antidepressants Provides information for those who work in the field of CNS drugs Ideal for pharmacologists, psychiatrists, and those who want to learn about CNS drugs at the graduate level

Autorentext

First Name - Kenji
Last Name - Hashimoto
Institution - Chiba University Center for Forensic Mental Health
Department - Division of Clinical Neuroscience
City - Chiba 260-8670
State - Chiba
Country - Japan
Email - hashimoto@faculty.chiba-u.jp

Kenji Hashimoto, PhD Chiba University, Chiba, Japan

Dr. Hashimoto is a professor and vice-director of Chiba University Center for Forensic Mental Health from 2005. Dr. Hashimoto graduated from Faculty of Pharmaceutical Sciences at Kyushu University, and received PhD. After Dr. Hashimoto worked at Fukuyama University, National Institutes of Health (NIH)/National Institute of Drug Addiction (NIDA)(Baltimore, MD, USA) and Pharmaceutical company, he moved at Chiba University Graduate School of Medicine from 2001. Dr. Hashimoto works on the development of novel therapeutic drugs for psychiatric and neurological disorders. Dr. Hashimoto published more than 550articles in PubMed listed publications. Dr. Hashimoto focus on the molecular and cellular mechanisms of ketamine's antidepressant actions.

Klappentext

(R)-ketamine: A new rapid-acting antidepressant.- (2R,6R)-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms.- Predictable biomarkers for rapid-acting antidepressant response to ketamine.- Nitrous Oxide: an old compound with emerging psychotropic properties.- Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants.- AMPA receptor potentiators as potential rapid-acting antidepressants.- mGlu2/3 receptor antagonists as rapid-acting antidepressants.- Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.

Inhalt
( R )-ketamine: A new rapid-acting antidepressant.- (2 R ,6 R )-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms.- Predictable biomarkers for rapid-acting antidepressant response to ketamine.- Nitrous Oxide: an old compound with emerging psychotropic properties.- Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants.- AMPA receptor potentiators as potential rapid-acting antidepressants.- mGlu2/3 receptor antagonists as rapid-acting antidepressants.- Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.