Neuroreceptors and Signal Transduction

Since the first Hiroshima Symposium of Neurotransmitter Receptors in 1983, there have been conspicuous advances in this field. For instance, our knowledge on transmembrane signalling mechanism has increased almost exponentially and this great stride has been linking areas of biology that had been previously considered of as being separate. The Second Hiroshima International Neurotransmitter Receptor Symposium was held on October 6 to 9 bringing together an outstanding group of neuroscientists from various disciplines to integrate these advances in the hope that their valuable contributions will make this meeting a tradition in this city. The original title of the Symposium was "Receptor Mechanism of Neurotransmitter and Neuropeptides". This volume is based on papers presented at this Second Hiroshima Symposium. Our aim editing this book is to discuss various neurotransmitter receptors in terms of their structural and biochemical properties, functions, ligands and related intracellular control mechanism, and to know the general denominators of all receptors. The editors believe that this book will provide a useful state-of-the-art summary of neuroreceptor fields at present and profit for those who could not participate in the Hiroshima Conference vicariously by reading the texts included in this volume. The editors acknowledge the help of many friends and colleagues in making this book possible. We are especially grateful to Dr. Shinobu Inagaki, former assistant professor of Third De-partment of Internal Medicine, Hiroshima University School of Medicine who made the Symposium successful as secretary-general through her devoted efforts. In 1988, Dr.

Inhalt
The GABA Receptor-chloride Ion Channel Protein Complex.- Biochemical and Functional Properties of Purified GABA Receptor/Benzodiazepine Receptor/Chloride Channel Complex and Application of its Antibody for Immunohistochemical Studies.- Molecular Biology of the GABAA Receptor.- GABA-activated Chloride Channels in the Retinal Neurons and Their Role in the Visual Function.- Effects of Hypoxia on Muscarinic Cholinergic and Benzodiazepine/?-Aminobutyric Acid Receptors in the Rat Brain.- Localization of the Glycine Receptors in the Rat Central Nervous System: An Immunocytochemical Analysis.- Studies of Multiple Morphine and Enkephalin Receptors: Evidence for Mu1 Receptors.- Evidence for Cholecystokinin Receptor and Intracellular Signal Transduction in Relation to Amylase Secretion.- Multiple Bradykinin Receptors: Results of Studies Using a Novel Class of Receptor Antagonists.- Receptor-stimulated System Mediated Interactions of Neuropeptides in CH3 Cells.- In Vitro Studies on Relationships Between Muscarinic Receptors and Somatostatin in the Rat Brain.- A Library of Monoclonal Antibodies for Exploring Unknown Functional Molecules on the Surface of Synaptic Membrane.- Application of Fast Reaction Techniques to Kinetic Measurements of Receptor Function on Cell Surfaces.- Cloning and Expression of Adrenergic and Muscarinic Cholinergic Receptor Genes.- In Vivo PET and SPECT Receptor Imaging: New Technology and Tactics for Receptor Measurement.- The Phosphoinositide-linked CNS Muscarinic Receptor.- Interactions Between Neurotransmitters that Regulate cAMP and Intracellular Ca2+ Levels in the CNS.- Regulation of Phosphoinositide Hydrolysis by GTP-Binding Proteins, Phorbol Esters and Botulinum Toxin Type D.- Biochemical Studies on the Muscarinic Acetylcholine Receptor.- AgonistBindings and Their Relationship to Receptor Responses in Heart Muscarinic Receptors.- Correlation Between the Binding Parameters of Muscarinic Agonists and their Inhibition of Adenylate Cyclase Activity.- Possible Roles of Protein Kinase C in Neurotransmission.- Changes in Apparent Functions of Component Proteins of Adenylate Cyclase System in Rat Brain by Drugs Acting on the Central Nervous System.- Function and Mechanism of the Interaction of GTP-Binding Proteins with ?2-Adrenoceptors in the Brain.- Existence of a 5-HT1 Binding Site Different of 5-HT1A, 5-HT1B, and 5-HT1C Suttypes and Coupled to a High Affinity Adenylate Cyclase Activation: A Functional 5-HT Receptor Involved in Neuromodulation ?.- Phospholipid Methylation Participates in H2-Receptor Mediated Stimulation of Adenylate Cyclase in Rat Brain.- Histaminergic Neuron System and Its Function.- Contributors.