This Springer Major Reference Work provides a detailed translational overview of neuroimmune diseases for neuroscientists and clinicians, clarifying the pathological mechanisms underlying neuroimmune diseases and building a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The new edition features updated chapters throughout, including coverage of new findings, new diagnostic criteria, and therapeutic algorithms. Neuroimmune Diseases, 2nd edition, also includes new chapters with a translational approach. The book will be invaluable for use in clinical practice of neuroimmune diseases.

Innovative approach, builds from basic pathogenic mechanisms to diagnosis and therapies Provides translational overview of the mechanisms behind neuroimmune diseases Highlights challenges related to neuroimmune disorder

Autorentext

**Hiroshi Mitoma MD, PhD, **is Professor of Department of Medical Education at Tokyo Medical University, Japan. He is also the Vice President for education at  Tokyo Medical University. Research activities have span from basic science approaches in animal models to neurological investigations with special focus on immune-mediated cerebellar ataxias.

Mario Manto, MD, PhD, is Professor of Neuroanatomy and Professor of Neurology at the University of Mons, Belgium. He is Head of the Department of Neurology at the CHU-Charleroi, Belgium. He is Editor of The Cerebellum (Springer Nature). He has written or edited 15 books in the field of clinical/experimental neurosciences.

Inhalt

Fundamental mechanisms and general principles.- Overview of mechanisms underlying neuroimmune diseases.- Principles in effecter T cells.- The roles of Th17 Cells in immunopathogenesis of neuroinflammatory disorders.- Significance of autoantibodies.- Immune tolerance in autoimmune central nervous system disorders.- The roles of regulatory T cells in central nervous system autoimmunity.- Disruption of the blood-brain barrier during neuroinflammatory and neuroinfectious diseases.- Structural and functional characteristics of the human blood-nerve barrier with translational implications to peripheral nerve autoimmune disorders.- Multi-actions of microglia.- Autoimmune astropathy.- The intestinal neuro-immune axis.- Genetic factors in neuroimmune diseases.- General principles of immunotherapy in neurological diseases.- Tageted therapies - Disorders : diagnosis and therapies.- Post-infectious immune mediated neurological diseases.- SARS-Cov2-mediated-neuroinflammation.- Vaccine-induced thrombotic thrombocytopenia related to COVID-19 vaccination.- Paraneoplastic neurological syndromes.- Multiple sclerosis.- Neuromyelitis optica spectrum disorder.- Atypical inflammatory demyelinating syndromes of the central nervous system.- GFAP astrocytopathy.- Central nervous system vasculitis .- Autoimmune Limbic encephalitis.- Rasmussen encephalitis.- Autoimmune ataxia.- Stiff-Person Syndrome Spectrum Disorders.- Sjgren's syndrome and neuroinflammation.- Behçet's syndrome and the nervous system involvement.- Neurosarcoidosis.- Uveomeningitis.- Anti-IgLON5 syndrome: a cross talk between autoimmune and taupathgy.- Neuroinflammation in Alzheimer' s disease.- Neuroinflammation in Parkinson's disease.- Guillain-Barré syndrome.- Chronic inflammatory demyelinating polyneuropathy.- Myasthenia gravis and other Immune-mediated disorders ofthe neuromuscular junction.- Myositis.