This volume aims at presenting the latest international research and discoveries in the neurocognitive aspects and complications in HIV/AIDS, and how this understanding can shape and inform how we think about clinical practice and patient care in HIV/AIDS as well as lead to a better understanding of the underlying neuropathogenesis.
The chapter, "Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders", of this book is available open access under a CC BY 4.0 license at link.springer.com

Leading cutting-edge research in HIV-associated neurocognitive impairments with Includes implications for clinical practice and care as well as enquiries into the putative neuropathogenesis There has not been a similar comprehensive update of the research since 2005 with the Neurology of AIDS series

Autorentext

Lucette A. Cysique, Ph.D is an Associate Professor and neuropsychologist at the University of New South Wales, Sydney, Australia and a visiting scholar at MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada. A/Prof. Cysique has been leading cross-disciplinary research into the neurocognitive and brain changes associated with HIV since 2009. A/Prof. Cysique has expertise in the measurement of cognitive trajectories in longitudinal cohort studies and clinical trials, and also contributes to the development of normative neuropsychological data for cross-sectional and longitudinal studies. Additionally, Dr. Cysique has extensive experience in cross-cultural neuropsychology.Sean B. Rourke, PhD is a clinical neuropsychologist and international expert in the neurobehavioral complications of HIV/AIDS. He is a scientist with MAP Centre for Urban Health Solutions in the Li Ka Shing Knowledge Institute of St. Michael's Hospital at Unity Health Toronto, a director for REACH Nexus funded by the Canadian Institutes of Health Research, and a professor of psychiatry at the University of Toronto. He is a Fellow with the Canadian and American Psychological Associations, and the Canadian Academy of Health Sciences. As a social entrepreneur his work involves novel approaches to community stakeholder engagement, partnership development across disciplines and sectors, and innovative research-to-action strategies for access to HIV testing and linkages to care (www.readytoknow.ca) and ending HIV stigma in Canada (www.positiveeffect.org).

Inhalt

I. Neuropathogenesis and Biomarkers.- New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment.- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection.- Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS.- Neuroimaging Advances in Diagnosis and Differentiation of HIV, Comorbidities, and Aging in the cART Era.- II. Neurocognitive Impairments in Low-, Middle- and High-Income Countries Incidence / Prevalence and Contexts.- Neurocognitive Complications of Pediatric HIV Infections.- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort.- Cultural Neuropsychology Considerations in the Diagnosis of HIV- Associated Neurocognitive Disorders.- Neurocognitive Complications of HIV Infection in Low-Income Countries.- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries.- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders.- III. Comorbidities and Complications.- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection.- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders.- Neuropsychiatric Disorders, Emotional Disturbances, and Their Associations with HIV-Associated Neurocognitive Disorder.- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders.- HIV-Associated Neurocognitive Disorder (HAND): Relative Risk Factors.- IV. Screening, Interventions and Clinical Management.- Screening for HIV-Associated Neurocognitive Disorders: Sensitivity and Specificity.- Behavioral and Physical Activity Interventions for HAND.- Targeting HIV-Related Neurocognitive Impairments with Cognitive Training Strategies: Insights from the Cognitive Aging Literature.- Clinical Treatment Options and Randomized Clinical Trials for Neurocognitive Complications of HIV Infection: Combination Antiretroviral Therapy, Central Nervous System Penetration Effectiveness, and Adjuvants.