This volume brings together pre-clinical and clinical research on topics highly relevant to the development and improvement of our understanding of Alzheimer's disease (AD). The combination of both research areas will appeal to a broad range of researchers from basic scientists to neurologists. The topics cover both established and more recent areas of research on the underlying causes of this disease which are still not fully understood more than 100 years after its first description by Alois Alzheimer. This broad perspective demonstrates how research into AD is evolving along with considering clinical aspects of the disease. The chosen contributors are well-placed to provide expert views on these topics. The book is divided into 2 sections, pre-clinical research and clinical research. While each section contains unique topics, there are also topics common to both areas such as Down Syndrome, considerations of diversity and behavioural and neurobiological symptoms of dementia to provide a wider perspective on these topics. The inclusion of Down Syndrome demonstrates the reverse translation of knowledge from the clinic to laboratory-based neurobiology. The two main sections are then further subdivided into groups for related topics. The broad overview of this book will encourage researchers to pursue bold and innovative research to expand knowledge of this complex neurodegenerative disease and to improve its detection, diagnosis, treatment, and management.

Brings together pre-clinical and clinical work on key areas in Alzheimer's disease research From mechanisms underlying Alzheimer's disease to potential drug targets and clinical trials Considers Down Syndrome and tau from both neurobiological and clinical perspectives

Inhalt

The involvement of the complement system in Alzheimer's disease.- Animal models to investigate depression and Alzheimer's disease.- Cholinergic system structure and function in individuals with Down Syndrome during the development of Alzheimer's disease.- Considerations of biological sex for research on Alzheimer's disease.- The contribution of the renin angiotensin system to Alzheimer's disease.- Hearing loss and Alzheimer's disease.- Cognitive decline in Alzheimer's disease.- What can we learn from people with Down Syndrome about Alzheimer's disease.- Getting diversity in clinical trials for AD.- Behavioral and neuropsychiatric symptoms and Alzheimer's disease Development and treatment.- The involvement of the complement system in Alzheimer's disease.