Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

Includes supplementary material: sn.pub/extras

Klappentext
Although neural stem cells (NSCs) have been successfully used in animal models of various neurodegenerative diseases and of brain and spinal cord injuries, their use in studies of nervous system dysfunction is still in its infancy. In Neural Stem Cells for Brain and Spinal Cord Repair, active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated,dysfunctional, or maldeveloped cells to the provision of factors (either produced intrinsically by the cells or induced to do so following genetic engineering) that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.

Inhalt
I: Stem Cells for and from the CNS: Their Source and Fundamental Properties.- 1 • Sources of Cells for CNS Therapy.- 2 • Neural Stem Cells and Their Plasticity.- 3 • Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells.- 4 • Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells.- 5 • The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood.- II: In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS.- 6 • Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation.- 7 • Neural Stem/Progenitor Cell Clones or Neurospheres: A Model for Understanding Neuromorphogenesis.- 8 • Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives.- 9 • Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair.- 10 • Neural Stem Cells in the Adult Hippocampus.- III: Stem/Progenitor Cells in Representative TherapeuticParadigms for the CNS.- 11 • Global Gene and Cell Replacement Strategies via Stem Cells.- 12 • Neural Stem Cells in and from the Spinal Cord.- 13 • Stem Cells for Spinal Cord Injury.- 14 • Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally GraftedNeural Precursors and Human hNT Neurons.- 15 • Utilization of Marrow Stromal Cells for Gene Transfer into the CNS.- 16 • Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy.