Natural products have a long history of use as folk medicines in several systems of traditional medicine. Extensive evidence from modern pharmacological studies has confirmed traditional applications, and unveiled the vast potential of naturally occurring compounds, particularly plant-derived phytochemicals, in the management of chronic human diseases. The past decade has witnessed a surge of findings from randomized controlled trials testifying the safety and efficacy of natural products as adjuncts or alternatives to standard-of-care medications for several illnesses. Biomolecular studies have unveiled hundreds of cellular and molecular targets for phytochemicals including key transcription factors, receptors, enzymes, hormones, neurotransmitters, cytokines, lipids, and non-coding RNAs. Extensive research on the preventative and therapeutic effects of natural products necessitates regular updating of the literature as to the developing potential roles of these compounds in different human diseases.

This new edition takes a more focused approach and center the theme around the antimicrobial properties of natural compounds. The book is organized into four comprehensive and cohesive sections covering antibacterial, antiviral, antifungal, and antiparasitic phytochemicals. Given the growing global concern over infectious and microbial diseases, this book is an urgently needed resource for researchers interested in learning more about natural products.

Provides insight into the clinical and translational application of natural products in human diseases Details the impact of natural products on a molecular basis Describes the identification of biomarkers, therapeutic effects of phytochemicals, and new targets

Autorentext

Amirhossein Sahebkar, PharmD., PhD., is Associate Professor of Pharmaceutical Biotechnology in the School of Pharmacy at the Mashhad University of Medical Sciences in Iran, and Honorary Research Fellow in the School of Health and Medical Sciences at the University of Western Australia. He has published more than 1100 articles on areas including blood lipids, neurovascular diseases, modern medical treatments in cellular, molecular, and animal tissues, and atherosclerosis. He is a highly cited researcher in the field of Pharmacology and Toxicology and has an h-index of 85.

Thozhukat Sathyapalan, MD., FRCP., FACP., is the Chair in Academic Diabetes, Endocrinology and Metabolism in Hull York Medical School, University of Hull and Honorary Consultant Endocrinologist at Hull and East Yorkshire Hospitals NHS Trust, United Kingdom. His main area of interest is on modulation of cardiometabolic risk through pharmacological and nutritional interventions. He has conducted several clinical trials in this area. He has also published and presented extensively in this field.

Inhalt

11. Natural Compounds as Multi-Target Therapeutics in Diabetes: Mechanistic Insights and Metabolic Benefits.- 2. Hepatoprotective Effect of Trehalose: Insight into Its Mechanisms of Action.- 3. Polyphenols as Potential Therapeutics in Traumatic Brain Injury: Mechanisms and Efficacy.- 4. Advances in Nutraceuticals and Bioactive Compounds for the Management of Periodontitis: An Updated Clinical Review.- 5. Vitamin D and Risk of COVID-19: a review of literature.- 6. Herbal Therapeutics and Bioactive Naturals: Clinical Insights into Plasma Adiponectin Modulation.- 7. The potential beneficial effects of ginger against COVID-19: A literature review.- 8 From Bench to Clinic: Updated Evidence on Curcumin's Role in Protecting Male Fertility.- 9. The beneficial effects of Selenium on COVID-19: a literature review.- 10. Exploring Curcumin's Renoprotective Potential in Diabetic and Non-Diabetic Kidney Diseases .- 11. The Multifaceted Actions of Curcumin in Obesity.- 12. Curcumin as a Nutraceutical Intervention in Pulmonary Hypertension: Mechanisms, Evidence, and Future Directions.-13. Green tea: A comprehensive review with a focus on COVID-19 biomarkers.