Presenting individual research contributions from scientists in the NIAID, this volume provides new research findings in immunology, infectious diseases, and vaccine research. Readers will find the current work in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC).

**National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research ** contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research.

This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories.

Contains individual research contributions by internationally known scientists doing research in the NIAID laboratories Covers new research findings in immunology, infectious diseases, and vaccine research Three-volume set will make the current state-of-the-art advancements of biomedical research available to the scientific community worldwide

Inhalt
Microbiology: Virology.- The Evolution of Gammaretrovirus Restriction Factors in the Mouse.- Herpesvirus Research at the National Institute of Allergy and Infectious Diseases: Thirty Years of Progress.- Why Study Mouse Retroviruses?.- Functions of the Rotavirus RNA Polymerase in Virus Replication.- Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia.- Microbiology: Human Immunodeficiency Virus (HIV).- Roles for Chemokine Receptors in HIV Pathogenesis.- HIV-1 Accessory Proteins: Crucial Elements for Virus-Host Interactions.- Microbiology: Bacteriology.- Exploring the Cause of Human Q Fever: Recent Advances in Coxiella burnetii Research.- Plague in the 21st Century: Global Public Health Challenges and Goals.- Molecular Biology of Staphylococcal Pathogenesis.- Investigations of Relapsing Fever at Home and Abroad.- Molecular Sleuthing with the Lyme Disease Agent.- Modeling of Acute Respiratory Melioidosis and Glanders.- Microbiology: Mycology.- Cryptococcosis: From Discovering the Natural Reservoir of its Etiology to the Genetic Manipulation of Cryptococcus neoformans: Milestones in Cryptococcal Research by Intramural Investigators at NIAID.- Microbiology: Parasitology.- Lessons from Parasites on CD4+ T-Cell Subset Differentiation and Function.- Molecular Aspects of Parasite Vector Interactions In Leishmaniasis.- Microbiology: Malaria.- Mosquito Strategies Against Plasmodium: A Tale of Restrained Response and Immune Evasion.- The Plasmodial Surface Anion Channel: A Model Microbial Ion Channel and Target for Antimalarial Drug Development.- Genomics and Genetics of Drug Resistance and Regulation of Malaria Parasite Development.- Immunology: Cellular Immunology.- Modulation of Human Dendritic Cells by Highly Virulent Pathogens.- Making Friends in Out-of-the- Way Places: How Cells of the Immune System Get Together and How They Conduct Their Business as Revealed by Intravital Imaging.- Role of Regulatory/Suppressor T Cells in Immune Responses.- Proliferation versus Contraction of Immune Cells, the Non-Apoptotic Role of Caspase 8 In Immune Homeostasis.- Features of Plasma Cell-Related Neoplasms in Mice.- A Role of IRF8 in Transcriptional Control of B-Cell Development.- Laboratory of Molecular Immunology.- Immunology: The Role of Receptors.- Structure and Function of Immunoreceptors.- Role of the NKG2D Receptor in Health and Disease.- Allergy.- G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease.- Mast Cell Precursors and Signaling Pathways.- Clinical Medicine: Infectious Diseases.- Prion Biochemistry and Therapeutics.- Neutrophils in the Resolution of Infection.- Reactive Oxidant-Dependent Innate Immune Defenses of the Airway Epithelium: The Dual Oxidase-Lactoperoxidase-Thiocyanate System.- Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease.- Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model.- The 1918 InfluenzaPandemic: Pathology and Pathogenesis.- Clinical Medicine: Autoimmune Diseases.- Mind Your Xs and Ys: Genetics of the Autoimmune Disease Systemic Lupus Erythematosus.- A Bench-to-Bedside Trail of Research Leading to the Understanding and Treatment of Ulcerative Colitis.- Clinical Medicine: Vaccines.- Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses.- How Do You Say B-Cell Biology In Vaccinology: Translational Research In the NIAID.- Malaria Vaccine Development.- The Development of Live-Attenuated Vaccines for Pandemic Influenza.- Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission.