This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. For the editors this term includes Ph-positive chronic myeloid leukemia but also the various Ph-negative variants, some of which provide fascinating insights into the molecular mechanisms of leukemia. There have been many recent developments in understanding the Pathophysiology and a number of therapeutic innovations in this area. One particular merit of this book is the speed with which it has been produced an important factor in this very rapidly moving field.

Very up-to-date book in this rapidly moving field Written by internationally renowned academics Ph-positive chronic myeloid leukemia are also included like the ph-negative variants Insights into the molecular mechanisms of the leukemias Includes supplementary material: sn.pub/extras

Inhalt
Chronic Myeloid Leukemia A Brief History.- Bcr-Abl and Signal Transduction.- Chronic Myeloid Leukemia: Biology of Advanced Phase.- Clinical Features of CML.- Signal Transduction Inhibitors in Chronic Myeloid Leukemia.- Treatment with Tyrosine Kinase Inhibitors.- Allogeneic Transplantation for CML.- Autografting in Chronic Myeloid Leukemia.- Monitoring Disease Response.- New Therapies for Chronic Myeloid Leukemia.- Immune Therapy of Chronic Myelogenous Leukemia.- Therapeutic Strategies and Concepts of Cure in CML.- BCR-ABL-Negative Chronic Myeloid Leukemia.- Hypereosinophilic Syndrome.- Chronic Idiopathic Myelofibrosis.- Polycythemia Vera Clinical Aspects.- Polycythemia Vera and Other Polycythemic Disorders Biological Aspects.- Essential Thrombocythemia.