This book reviews the state-of-the-art in multiscale computer modeling, examining both its accomplishments and its challenges. Helps connect traditional biomedical engineering at the organ and tissue scale with cellular and molecular bioengineering.

This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.

Develops computer models and simulations of the same problem at different hierarchical scales Reviews the state-of-the-art in multiscale computer modeling of the current frontiers in the biosciences Bridges between traditional biomedical engineering work and the newer arenas of cellular and molecular bioengineering Includes supplementary material: sn.pub/extras

Inhalt

Application of neural network and finite element method for multiscale prediction of bone fatigue crack growth in cancellous bone.- Multiscale approach to understand the multiphysics phenomena in bone adaptation.- Multiscale elastic models of collagen bio-structures: from cross-linked molecules to soft tissues.- Multiscale modeling of ligaments and tendons.- Multiscale modeling of lymphatic drainage.- A model of electromechanical coupling in the small intestine.- Multi-scale computational modeling in vascular biology: from molecular mechanisms to tissue-level structure and function.- Multiscale modeling in vascular disease and tissue engineering.- Translational research: Multi-scale models of the pulmonary circulation in health and disease.- A multilevel finite element approach to study pressure ulcer aetiology.- Discrete and continuum multiscale behaviour in bacterial communication.- Wound healing: Multi-scale modeling.- Modeling multiscale necrotic and calcified tissue biomechanics in cancer patients: application to ductal carcinoma in situ (DCIS).- Integration of molecular signaling into multiscale modeling of cancer.