This textbook builds on the success its two previous editions, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections, and explores the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels.

Designed for a one-semester course at either the graduate or advanced undergraduate level, this self-contained textbook provides all the necessary background in biochemistry and is written in accessible language. It discusses the latest developments in the field of antibiotics, emphasizing experimental procedures and interpretation of results, and frequently cites original research to support learning.

To help both students and instructors, the book includes approximately 500 multiple-choice questions on antibiotcs. Test your knowledge with questions and answers about this textbook with Springer Nature Flashcards.

Builds on success of earlier editions, with new strategies for discovering antibiotics Designed for a one-semester course on Antibiotics and Development of Resistance to Antibiotics Test your knowledge with questions and answers about the textbook with Springer Nature Flashcards

Autorentext

Mrinal Bhattacharjee did his Ph.D. from The Ohio State University and currently works as an Associate Professor at Long Island University where he teaches Biochemistry, Organic Chemistry and General Chemistry classes. His research interests include molecular biology of oral bacteria and discovery and study of new antibiotics especially from natural sources.

Inhalt

Chapter 1: Introduction.- Chapter 2: Development of resistance to antibiotics.- Chapter 3: Antibiotics that inhibit cell wall synthesis.- Chapter 4: Antimetabolites: Antibiotics that inhibit nucleotide synthesis.- Chapter 5: Antibiotics that inhibit nucleic acid synthesis.- Chapter 6: Antibiotics that inhibit protein synthesis.- Chapter 7: Antibiotics that affect the membrane and other structural targets.- Chapter 8: Antifungals, Antimalarials and Antivirals.- Chapter 9: Alternative Approaches for Antibiotic Discovery.- Chapter 10: Global Action Plan and Antibiotic Stewardship.- Index.