Jetzt 20% Rabatt auf alle English Books. Jetzt in über 4 Millionen Büchern stöbern und profitieren!
Willkommen, schön sind Sie da!
Logo Ex Libris

Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

  • Kartonierter Einband
  • 368 Seiten
(0) Erste Bewertung abgeben
Bewertungen
(0)
(0)
(0)
(0)
(0)
Alle Bewertungen ansehen
This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxi... Weiterlesen
20%
196.00 CHF 156.80
Sie sparen CHF 39.20
Exemplar wird für Sie besorgt.
Kein Rückgaberecht!
Bestellung & Lieferung in eine Filiale möglich

Beschreibung

This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of -6 and -3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.



This is the first book that provides up-to-date, comprehensive reviews on the monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450 enzymes in 13 chapters compiled by leading scientists in their field

This book is available in paper and electronic formats and will be helpful to researchers and graduate students in their areas

Customers should purchase this book as there are no recent books on the market that review the peroxidase and peroxygenase properties of cytochrome P450 enzymes

Includes supplementary material: sn.pub/extras



Inhalt
Foreword.- 1. Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes .- 2. Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants.- 3. Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions.- 4. Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1.- 5. Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples With Single Substrates.- 6. Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and their Role in Cardiovascular Disease.- 7. Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s.- 8. Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates,- 9. Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources.- 10. Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs .- 11. Biological Diversity of Cytochrome P450 Redox Partner Proteins .- 12. Cytochrome P450cin (CYP176A1).- 13. Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins that Combine Peroxidase and Cytochrome P450 Properties.

Produktinformationen

Titel: Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450
Editor:
EAN: 9783319347943
ISBN: 978-3-319-34794-3
Format: Kartonierter Einband
Herausgeber: Springer, Berlin
Genre: Medizin
Anzahl Seiten: 368
Größe: H235mm x B235mm x T155mm
Jahr: 2016
Untertitel: Englisch
Auflage: Softcover reprint of the original 1st ed. 2015

Weitere Produkte aus der Reihe "Advances in Experimental Medicine and Biology"