With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases.
Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Includes supplementary material: sn.pub/extras

Zusammenfassung
This work presents integrated coverage of recent advances in the molecular mechanisms of neurodegenerative diseases and describes how these mechanisms present new therapeutic targets.

Inhalt
1 A? Toxicity in Alzheimer's Disease.- 2 Transgenic Models of Alzheimer's Disease.- 3 Glial Cells in Alzheimer's Disease.- 4 Inflammation in Alzheimer's Disease.- 5 Proteolysis in Neurodegenerative Diseases.- 6 Treatment Approaches for Alzheimer's Disease.- 7 Tau and ?-Synuclein in Neurodegenerative Diseases.- 8 PET Investigations of Parkinson's Disease.- 9 Dopamine Neurotoxicity and Neurodegeneration.- 10 Mitochondria and Parkinson's Disease.- 11 Pathophysiology of SCA1.- 12 Pathophysiology of SCA3.- 13 Pathophysiology of Spinal and Bulbar Muscular Atrophy.- 14 Mouse Models of Huntington's Disease.- 15 Huntingtin-Associated Proteins.- 16 Modeling Neurodegenerative Diseases in the Fruit Fly.