This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance.

Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response.

Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Covers all aspects of gynecologic tumors, including uterine cervical/endometrial cancer and ovarian cancer in detail Explores the latest evidence-based approaches in the diagnosis and management of gynecologic tumor Bridges the gap between basic science and clinical practice Discusses topics related to hereditary gynecologic malignancy

Autorentext

Seiji Isonishi

Department of Obstetrics and Gynecology

The Jikei University School of Medicine

Minato-ku, Tokyo, Japan

Yoshihiro Kikuchi

Department of Gynecology

Ohki Memorial Kikuchi Cancer Clinic for Women

Tokorozawa, Japan

Inhalt

1 Cancer Stem Cells in gynecologic cancer.- 2 Patient-derived xenograft models in gynaecological malignancies.- 3 Cancer genomic profiling of gynecological malignancies by Todai OncoPanel, a twin DNA and RNA panel.- 4 Investigating the molecular carcinogenesis of ovarian high-grade serous cancer.- 5 The role of G protein-coupled receptor signaling in gynecologic malignancy.- 6 Tailor-made therapy according genetic alteration in epithelial ovarian cancers.- 7 Signaling and drug resistance.- 8 Molecular analysis in endometrial carcinoma.- 9 Molecular Landscape in Ovarian Clear Cell Carcinoma.- 10 Molecular pathology and clinicopathological significance of endometrial carcinoma.- 11 Novel approach for therapeutics of cervical cancer based on HPV-associated carcinogenesis at the cervix.- 12 Hereditary gynecological malignancy and molecular features.

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