'" Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body."

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Presents milestones and recent achievements of toxicology Explains mechanisms of toxicity at the molecular level Discusses toxicogenomics and individual variability

Inhalt
Historical milestones and discoveries that shaped the toxicology sciences.- Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment.- The role of biotransformation and bioactivation in toxicity.- Genotoxicity: damage to DNA and its consequences.- Role of DNA repair in the protection against genotoxic stress.- On the impact of the molecule structure in chemical carcinogenesis.- Chemical induced alterations in p53 signaling.- Molecular pathways involved in cell death after chemically induced DNA damage.- The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways.- Mapping the epigenome impact for toxicology.- Receptors mediating toxicity and their involvement in endocrine disruption.- Toxicogenomics: transcription profiling for toxicology assessment.- The role of toxicoproteomics in assessing organ specific toxicity.- High-throughput screening for analysis of in vitro toxicity.