Modern Neurosurgery of Meningiomas and Pituitary Adenomas

"Modem Neurosurgery of Meningiomas and Pituitary Adenomas" presents the state-of-the-art of neurosurgery for these two types of tumors. Following a classification of the pituitary adenomas according to pathology, molecular biological factors are presented and their effects evaluated as these aspects deepen our understanding of the growth and further expansion of these tumors. The diagnosis is made not only by a study of the hormonal status, but also by neuroradiology. A number of authors have devoted their efforts to the special problem groups such as the elderly patients and those with huge pituitary adenomas. Particular emphasis is of course placed on the surgical treatment, including transcranial and transphenoidal neurosurgery, but the use of medical treatment and irradiation must be discussed as well. The treatment of meningiomas has also been influenced by the molecular biology of hormone and growth factors. Therefore it is accorded extensive space in this volume. The prognostic significance of nuclear DNA content is discussed. Recent research with new diagnostic methods such as somatostatin scintigraphy, PET studies end progesterone receptor in tumor fragment spheroids is presented here. The treatment of these tumors, however, depends largely on their localization. For the neurosurgeon, the surgical treatment of meningiomas involving the cavernous sinus, meningiomas of the ventral Foramen of Monroe, meningiomas of the cerebello pontine angle and of the optic sheath is presented by prominent experienced leaders in this field.

Inhalt
Pituitary Adenomas.- Current Pathological Classification of Pituitary Adenomas.- Molecular Biological Research in Pituitary Adenomas from the Pathologists' View.- Molecular Biology of Growth-Hormone-Secreting Human Pituitary Tumours: Biochemical Consequences and Potential Clinical Significance.- Surgical Results in Microadenomas.- Management of Huge Pituitary Adenomas.- The Role of Transcranial Surgery in the Management of Pituitary Adenoma.- Proliferation Parameters for Pituitary Adenomas.- Protein Kinase C and Growth Regulation of Pituitary Adenomas.- MR Imaging of Residual Tumor Tissue After Transsphenoidal Surgery of Hormone-Inactive Pituitary Macroadenomas: A Prospective Study.- Persistent and Recurrent Hypercortisolism After Trans sphenoidal Surgery for Cushing's Disease.- Surgical Treatment of Pituitary Adenomas in Elderly Patients.- Combined Surgery and Radiotherapy of Invasive Pituitary Adenomas Problems of Radiogenic Encephalopathy.- LINAC-Radiosurgery (LINAC-RS) in Pituitary Adenomas: Preliminary Results.- Comparison of Thermoregulatory Characteristics of Patients with Intra-and Suprasellar Pituitary Adenomas.- Meningiomas.- The Molecular Biology of Hormone and Growth Factor Receptors in Meningiomas.- Hormonal Dependency of Cerebral Meningiomas.- Surgical Treatment of Meningiomas Involving the Cavernous Sinus: Evolving Ideas Based on a Ten Year Experience.- Meningiomas Involving the Parasellar Region.- Atypical and Malignant Meningiomas: Evaluation of Different Radiological Criteria Based on CT and MRI.- Prognostic Significance of Nuclear DNA Content in Human Meningiomas: A Prospective Study.- Correlation Between Cytogenitic and Clinical Findings in 215 Human Meningiomas.- Surgical Results of Spinal Meningiomas.- Microsurgical Management of Ventraland Ventrolateral Foramen Magnum Meningiomas.- Meningiomas of the Cerebellopontine Angle.- Management of Petroclival Meningiomas: A Critical Analysis of Surgical Treatment.- Symptomatology, Surgical Therapy and Postoperative Results of Sphenoorbital, Intraorbital-Intracanalicular and Optic Sheath Meningiomas.- Factors Influencing Morbidity and Mortality After Cranial Meningioma Surgery a Multivariate Analysis.- Clinical Relevance of Somatostatin Receptor Scintigraphy in Patients with Skull Base Tumours.- Progesterone Receptors in Tumor Fragment Spheroids of Human Meningiomas.- PET-Study of Intracranial Meningiomas: Correlation with Histopathology, Cellularity and Proliferation Rate.- Index of Keywords.