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Models for Assessing Drug Absorption and Metabolism

  • Kartonierter Einband
  • 468 Seiten
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Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures ... Weiterlesen
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Beschreibung

Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems. Chapters provide ready access to these methodologies for studies of the intestinal, buccal, nasal and respiratory, vaginal, ocular, and dermal epithelium as well as the endothelial and elimination barriers.

Inhalt

General Principles in the Characterization and Use of Model Systems for Biopharmaceutical Studies; R.T. Borchardt, et al. Methods for Evaluating Intestinal Permeability and Metabolism in vitro; P.L. Smith. Culturedintestinal Epithelial Cell Models; I.J. Hidalgo. Intestinal Rings and Isolated Intestinal Mucosal Cells; J.A. Fix. Models of Drug Absorption in situand in Conscious Animals; R. Griffiths, et al. Model Systems for Intestinal Lymphatic Transport Studies; C.J.H. Porter, W.N. Charman. Buccal Tissues and Cell Culture; E. Quadros, et al. Isolated Hepatocytes; M. Vore, et al. Cultured Rat Hepatocytes; E.L. Le Cluyse, et al. Isolated Perfused Liver; K.L.R. Brouwer,R.G. Thurman. Isolated Renal Brush Border and Basolateral Membrane Vesicles and Cultured Renal Cells; M.M. Gutierrez, et al. Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs: Information Obtained in Steadystate and Nonsteady State Experimental Systems; N. Okudaira, Y. Sugiyama. Brain Microvessel Endothelial Cell Culture Systems; K.L. Audus, et al. Methods to Study Drug Transport in Isolated Choroid Plexus Tissue and Cultured Cells; C.B. Washington, et al. Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System; Q.R. Smith. 8 additional articles. Index.

Produktinformationen

Titel: Models for Assessing Drug Absorption and Metabolism
Editor:
EAN: 9781489918659
ISBN: 1489918655
Format: Kartonierter Einband
Herausgeber: Springer US
Genre: Medizin
Anzahl Seiten: 468
Gewicht: 703g
Größe: H235mm x B155mm x T25mm
Jahr: 2013
Auflage: Softcover reprint of the original 1st ed. 1996