This volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and more. Throughout, numerous color photographs, diagrams of molecular pathways, and tables enhance the text.
microRNA: Basic Science is an ideal companion to both microRNA: Medical Evidenceand microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.

Focuses on innovative applications of microRNAs to obtain selective therapies in several disorders, not centered on cell proliferation and cancer Includes distinguished experts in the field, from prominent universities and with a strong record of scientific publications Provides systematic and extensive discussions of both biological features and clinical applications

Autorentext

Dr. Gaetano Santulli received his MD and PhD at the University of Naples Federico II. A physician scientist, Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an AHA fellowship and a Scientist Development Grant. Cardiologist, he authored more than 100 publications, including peer-reviewed articles in high impact journals, book chapters, and medical books. He is currently a faculty member of Columbia University. He lives in Manhattan. Dr. Santulli's expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, heart failure, arrhythmias, vascular disorders, and skeletal muscle disease. He is a member of several international academic societies, including New York Academy of Sciences, American Heart Association (AHA), American Diabetes Association, European Society of Cardiology, Endocrine Society, American Association for the Advancement of Science, European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions. He serves on the Editorial Boards of numerous medical Journals.

Inhalt

1. microRNA and personalized medicine 2. microRNA and mitochondria 3. microRNA and lipid metabolism 4. microRNA and beta cell physiology 5. microRNA and diabetic kidney disease 6. microRNA and chronic pain 7. microRNA and multiple sclerosis 8. microRNA and epilepsy 9. microRNA and autism 10. microRNA and Fragile X Syndrome 11. microRNA and Aging 12. microRNA and endometrial pathophysiology 13. microRNA role in human ovulation 14. microRNA in dermatology 15. microRNA and allergy Dr. Rebane 16. microRNA and hepatitis B 17. microRNA and NF-kappa B 18. microRNA and haematopoiesis 19. microRNA and malignant lymphoma 20. microRNA and pancreatic cancer 21. microRNA and colorectal cancer 22. microRNA and bone cancer 23. microRNA and soft tissue sarcoma Dr. Fujiwara 24. microRNA and doping 25. microRNA profiling 26. microRNA and cardiac arrhythmias 27. microRNA and heart failure 28. microRNA and Alzheimer's disease 29. microRNA and Parkinson's disease 30. microRNA delivery