This collection of diverse articles by the pioneers of modern genomics takes stock of the current state of the field and elucidates the contribution that sequencing genomes has made to our understanding of microbial metabolism and evolution. Through twenty-eight thought-provoking chapters, the authors describe some of the most common computational methods and their applications to studying pathogenic microorganisms, show how genomics can be used to reconstruct the history and dynamism of the microbial world, and discuss issues as diverse as reconstruction of metabolic pathways, cell cycle processes, microbial evolution, metagenomics, and vaccine development. Additional chapters deal with microarrays and expression analysis and the role of genomic in drug discovery.

Includes supplementary material: sn.pub/extras

Klappentext
Genomic technologies have transformed the field of microbiology, making it possible to investigate hundreds of genomes and uncover millions of new genes. In Microbial Genomics, a panel of genomics pioneers-many from The Institute for Genomic Research (TIGR)-take stock of the current state of the field. Through 28 thought-provoking chapters, the authors describe some of the most common computational methods and their applications to studying pathogenic microrganisms, show how genomics can be used to reconstruct the history and dynamism of the microbial world, and discuss issues as diverse as reconstruction of metabolic pathways, cell cycle processes, microbial evolution, metagenomics, and vaccine development. Additional chapters deal with microrarrays and expression analysis and the role of genomics in drug discovery.
Stimulating and comprehensive, Microbial Genomics brings together not only many of the major investigators of modern microbial genomics, but also synthesizes a coherent view of the contributions that sequencing has made to our understanding of genomic structures, evolution, and biology.

Inhalt
Part I: Introduction History of Microbial Genomics Hamilton O. Smith Part II: Bioinformatics As a Tool in Genomics Tools for Gene Finding and Whole Genome Comparison Steven L. Salzberg and Arthur L. Delcher Bacterial Genome Annotation at TIGR Owen White Bioinformatics and Microbial Pathogenesis Fiona S. L. Brinkman and Joanna L. Fueyo Bacteriophage Bioinformatics Derrick E. Fouts Part III: Core Functions Comparative Microbial Metabolism Karen E. Nelson Genomic Analysis of Membrane Transport Ian T. Paulsen, Katherine H. Kang, Mark E. Hance, and Qinghu Ren Genomics-Based Analysis of the Bacterial Cell Cycle Michael T. Laub, Harley H. McAdams, and Lucy Shapiro Part IV: The Evolution of Microbial Genomes A Brief History of Views of Prokaryotic Evolution and Taxonomy Lorraine Olendzenski, Olga Zhaxybayeva, and J. Peter Gogarten How Bacterial Genomes Change Timothy D. Read and Garry S. A. Myers Concepts of Bacterial Biodiversity for the Age of Genomics Frederick M. Cohan Coevolution of Symbionts and Pathogens With Their Hosts Robert A. Feldman Part V: A Survey of Microbial Genome A Survey of Plant Pathogen Genomes C. Robin Buell Anoxygenic Phototrophic Bacteria F. Robert Tabita and Thomas E. Hanson Genomics of Thermophiles Frank T. Robb The Genomes of Pathogenic Enterobacteria Julian Parkhill and Nicholas R. Thomson Obligate Intracellular Pathogens Siv G. E. Andersson Low G+C Gram-Positive Genomes Steven R. Gill Genomics of Actinobacteria, the High G+C Gram-Positive Bacteria Stephen D. Bentley, Roland Brosch, Stephen V. Gordon, David A. Hopwood, and Stewart T. Cole Parasite Genomics Malcolm J. Gardner Genome Sequence of an Extremely Halophilic Archaeon Shiladitya DasSarma Part VI: Applications of Genomic Data Microarrays, Expression Analysis, and Bacterial Genomes Carsten Rosenow and Brian Tjaden Microbial Population Genomics and Ecology: A New Frontier Edward F. Delong Application of Genomics to Biocatalysis and Biodegradation Lawrence P. Wackett Enzyme Discovery and Microbial Genomics Robert M. Kelly and Keith R. Shockley Integration of Genomics in the Drug Discovery Process Jacques Ravel A Genomic Approach to Vaccine Development Rino Rappuoli, Vega Masignani, Mariagrazia Pizza, Guido Grandi, and John L. Telford Microbial Proteomics Svend Birkelund, Brian B. Vandahl, Allan C. Shaw, and Gunna Christiansen Index