Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Gives an overview on Metallomics Provides an up-to-date information source for researchers Valuable for teaching/Inorganic Biochemistry courses

Autorentext

Members of our labs swiftly read the volume and scoured the chapters covering the metals relevant to each of their respective research projects. Everyone found gems of insight of value to their special interests & Labs working on Metals in Biology need a copy of Metallomics and the Cell and their numbers should grow - Andrew W. Foster, Carl J. Patterson, Nigel J. Robinson*, and Peter T. Chivers, Coord. Chem. Rev. 257 (2013) 3072-3073 this is a nice book that compiles the most important advances in metallomics from cellular and systems biology points of view. It provided convincing evidences that research on metallomics deserves further attention fromthe !eld of both chemistry and biology. It is amust for all researchers in the !eld of biological inorganic chemistry, and a useful resource for undergraduate teaching - Zijian Guo, J. Inorg. Biochem. 129 (2013) 172

Klappentext

Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, this book is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Lucia Banci is a bioinorganic chemist and a structural biologist who is studying, among various topics, metal transport and metal homeostasis processes. She is aiming towards a cellular perspective in the spirit of mechanistic systems biology, with the goal of describing functional processes with atomic resolution in a cellular context.

Inhalt

1. Metallomics: Some Definitions and General Comments by Lucia Banci and Ivano Bertini 2. Technologies for Detecting Metals in Single Cells by James E. Penner-Hahn 3. Sodium/Potassium Homeostasis in the Cell by Michael V. Clausen and Hanne Poulsen4. Cellular Magnesium Homeostasis in Mammalian Cells by Andrea M. P. Romani5. Intracellular Calcium Homeostasis and Signaling by Marisa Brini, Tito Cali, Denis Ottolini, and Ernesto Carafoli 6. Manganese Homeostasis and Transport by Jerome Roth, Silvia Ponzoni, and Michael Aschner7. Control of Iron Metabolism in Bacteria by Ian Norton, Arvindkumar S. Salunkhe, Helen Goodluck, Wafaa S. M. Aly, Hanna Mourad-Agha, Pierre Cornelis, and Simon Andrews 8. The Iron Metallome in Eukaryotic Organisms by Adrienne C. Dlouhy and Caryn E. Outten9. Heme Uptake and Metabolism in Bacteria by David R. Benson and Mario Rivera10. Cobalt and Corrinoid Transport and Biochemistry by Valentin Cracan and Ruma Banerjee11. Nickel Metallomics: General Themes Guiding Nickel Homeostasis by Andrew M. Sydor and Deborah B. Zamble12. The Copper Metallome in Prokaryotic Cells by Christopher Rensing and Sylvia Franke McDevitt 13. The Copper Metallome in Eukaryotic Cells by Katherine E. Vest, Hayaa F. Hashemi, and Paul A. Cobine 14. Zinc and the Zinc Proteome by Wolfgang Maret 15. Metabolism of Molybdenum by Ralf R. Mendel16. Comparative Genomics Analysis of the Metallomes by Vadim N. Gladyshev and Yan Zhang