Medullary Thyroid Carcinoma

Medullary Thyroid Carcinoma is a rare thyroid tumor originating from neural crest cells, the C-cell that implies several special features, secretion of different neuroendocrine markers, association with other endocrine tumors and familial appearance. The familial variant of medullary thyroid carcinoma allows an early detection by biochemical and genetic testing. At that stage acceptable surgical treatment will cure the patient. The sporadic form of medullary thyroid carcinoma will be diagnosed in a progressive stage, but adequate surgical procedure can cure these patients too. Long term survival depends on stage, age, sex, and variant of the disease and seems to be as good as in other differentiated thyroid cancers.

Inhalt
Biological Aspects of Medullary Thyroid Carcinoma.- Regulation of Calcitonin Secretion and Calcitonin Gene Expression.- Pathology of Sporadic and Hereditary Medullary Thyroid Carcinoma.- Epidemiology of Medullary Thyroid Carcinoma.- Clinical and Diagnostic Aspects of Medullary Thyroid Carcinoma.- Tumor Markers for the Medullary Thyroid Carcinoma.- Sporadic Medullary Thyroid Carcinoma: Clinical Features and Diagnosis.- Screening for MEN 2 with Biochemical and Genetic Markers.- Imaging Methods for Medullary Thyroid Cancer.- Therapeutic Procedure in Medullary Thyroid Carcinoma.- Surgical Strategies and Methods for the Treatment of Metastasizing Medullary Thyroid Carcinoma.- Surgical Management of MEN 2.- Postsurgical Follow-Up and Management.