This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Highlights recent advances in disease modeling, emerging technologies, and iPSC applications Presents latest iPSC technologies Offers an indispensable resource for a wide community of researchers and clinicians

Autorentext
Haruhisa Inoue, CiRA, Kyoto University, Japan; RIKEN BRC, Japan; RIKEN AIP, JAPAN
Yukio Nakamura, RIKEN BioResource Center, Japan

Inhalt

Introduction. Overview.- Disease Modeling. iPSCs for disease modeling.- Reprogramming cancer cells.- Recapitulating hematopoiesis in the lab.- Modeling cardiomyopathies with iPSCs.- Molecular Technologies. Controling cell state with intracellular biomarkers.- Genome editing of stem cells.- iPS Applications. iPSC-based cell therapy for eye diseases.- 3D models for organ development.- Drug discovery using iPSCs.- Direct differentiation of neural cells.