This book integrates topics in basic research and clinical medicine as well as molecular and cell biology.

It presents innovative advances in the field of immunodeficiency syndromes and viral/bacterial respiratory infections, including a novel hyperbaric oxygen treatment for COVID-19. A comprehensive insight is offered into the unresolved molecular pathways in chemosensing that plays a vital role in detecting insufficient tissue oxygenation, as well as in sporting accomplishments. Other articles address cardiorespiratory and humoral responses to hypoxia, the function of cementum in the repair and regeneration of teeth, and periprosthetic fractures following hip arthroplasty in the elderly. The issue of the overwhelming burdens on caregivers to spinal injury patients, damaging both health and psychosocial status, is addressed.

The book promotes translation of scientific advances to the general medical practice. It will be a valuable reference for clinical healthcare professionals and researchers interested in innovative practices to improve the prevention, diagnosis, and management of diseases.

Comprehensive insights into the high-risk and rare diseases Cutting-edge presentation of advancements in medical sciences Reflection on the multidisciplinary nature of pathologic conditions Resource of the basic science underlying the homeostatic mechanisms

Inhalt
Role of IP3 Receptors in Shaping the Carotid Chemoreceptor Response to Hypoxia but not to Hypercapnia in the Rat Carotid Body: An Evidence Review.- The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review.- Primary Immunodeficiencies - Diseases of Children and Adults: A Review.- Pneumococcal Vaccine in Adult Asthma Patients.- Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and without History of Allergy.- Pruritus Characteristics in Severe Atopic Dermatitis in Adult Patients.- Pathophysiological Responses to a Record-Breaking Multi-Hour Underwater Endurance Performance: A Case Study.- Respiratory Muscle Strength and Ventilatory Function Outcome: Differences between Trained Athletes and Healthy Untrained Persons.- Uroflowmetry and Altitude Hypoxia: A Report from Healthy Italian Trekkers and Nepali Porters during Himalayan Expedition.- Effects of Intraligamentary Injection of Osteogenic-Induced Gingival Fibroblasts on Cementum Thicknessin the Dog Model of Tooth Root Resorption.- In-Silico Evaluation of Treatment of Periprosthetic Fractures in Elderly Patients after Hip Arthroplasty.- Appraisal of burden of caregivers to chronically rehabilitated patients with spinal cord injuries in a tertiary neurological center in Nepal.