During the last five years the histological classification of the non-Hodgkin lymphomas has become a complex subject. Even experienced pathologists and clinicians find it increasingly difficult to make their way through the extensive and often confusing literature. The confusion is mainly due to the fact that different "schools" use different starting points for their classifica tion. Moreover, since many immunological problems related to classifica tion have not been completely resolved yet, even researchers who use the same approach do not always arrive at the same classification scheme. This book represents an attempt to find common elements in three most important classifications for non-Hodgkin lymphomas (the Rappaport classification, the Lukes-Collins classification and the Kiel classification) and to provide a scientific basis for the classification of this disease group. It therefore defines the two main groups of lymphocytes and their specific distribution pattern in the lymphoid organs and discusses the methods by which these cells and related tumors can be recognized. The various malignant B- and T-cell lymphomas are described in detail by expert authors, who deal not only with the morphological details, but also with the relevant clinical aspects. Finally, some related special topics are dealt with to complete the contents of this book. SECTION I BASIC CONCEPTS AND METHODOLOGY IN LYMPHOMA CLASSIFICA TION 1. HISTOPHYSIOLOGY OF NORMAL LYMPHOID TISSUE AND IMMUNE REACTIONS P. NIEUWENHUIS AND K. LENNERT INTRODUCTION Not so long ago (1) the lymphocyte was defined as:" . . .

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I. Basic Concepts and Methodology in Lymphoma Classification.- 1. Histophysiology of normal lymphoid tissue and immune reactions.- 2. Development and differentiation of the T-cell and B-cell systems: a perspective.- 3. B-cell differentiation and characterization.- 4. T-cell differentiation and characterization.- 5. Different reticulum cells of the lymph node: microecological concept of lymphoid tissue organization.- 6. HLA studies in malignant lymphomas.- 7. Regulatory properties of T lymphocytes: implications for studies on malignant lymphoid cells.- 8. Immunological approach to lymphoid neoplasms.- 9. Immunoperoxidase techniques in lymphoma research.- 10. Immunofluorescence methods.- 11. Cytochemical methods.- 12. Electron microscopy in the study of human lymphomas.- 13. Changing concepts in the classification of lymphoma.- II. B-cell Lymphomas.- 14. The functional approach to the pathology of malignant lymphomas.- 15. Germinal center cell lymphomas and the Kiel classification.- 16. Malignant lymphomas of germinal center cell origin: prevalence, type of presentation, stages and survival (preliminary data).- 17. Immunoglobulin expression in B-cell leukemias and B-cell lymphomas.- 18. Lymphoplasmacytic/lymphoplasmacytoid lymphoma (LP immunocytoma) (modified abstract).- 19. Lymphoproliferative diseases and monoclonal gammopathy.- 20. Immunoblastic lymphoma arising in angioimmunoblastic lymphadenopathy.- 21. Interrelations of B-cell neoplasms.- 22. Clinical manifestations, staging, and management of the non-Hodgkin's lymphomas: an overview.- III. T-cell Lymphomas.- 23. T-cell derived neoplasms: an overview.- 24. T-cell neoplasia in the perspective of normal T-cell differentiation.- 25. Clinical manifestations of T-cell lymphomas.- 26. Cutaneous T-cell lymphoma:morphological and immunological aspects.- 27. Cutaneous T-cell lymphomas: clinical aspects.- 28. Systemic manifestations of mycosis fungoides.- 29. Early involvement of lymph nodes in mycosis fungoides.- IV. Hodgkin's Disease.- 30. Natural history of Hodgkin's disease in relation to non-Hodgkin's lymphoma.- 31. Immunopathology of Hodgkin's disease.- 32. The results of the treatment of Hodgkin's disease: an overview of current approaches and future directions.- V. Special Topics.- 33. Epithelioid cellular lymphogranulomatosis (lymphoepithelioid cell lymphoma): histologic and clinical observations.- 34. The pathology of childhood lymphomas.- 35. Extranodal lymphomas.- 36. Hairy-cell leukemia.- 37. The prognostic relevance of leukemic cell typing in acute lymphoblastic leukemia.- 38. The significance of fine-needle aspiration cytology for the diagnosis and treatment of malignant lymphomas.