Klappentext

Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).

Inhalt
Defining Neural Stem Cells and Their Role in Normal Development of the Nervous System Sally Temple Neural Stem Cells in the Adult Brain: Implications of Their Glial Characteristics Daniel A. Lim and Arturo Alvarez-Buylla Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny Larysa Halyna Pevny Multipotent Stem Cells in the Embryonic Nervous System Ali Jalali, Michael Bonaguidi, Caitilin Hammill, and John A. Kessler Regulation of Neural Stem Cell Death Rizwan S. Akhtar and Kevin A. Roth Neuronal Progenitor Cells of the Mammalian Neonatal Anterior Subventricular Zone Douglas L. Falls and Marla B. Luskin Glial Restricted Precursors Mark Noble and Margot Mayer-Proschel PNS Precursor Cells in Development and Cancer Houman D. Hemmati, Tanya A. Moreno, and Marianne Bronner-Fraser Stem Cells of the Adult Olfactory Epithelium James E. Schwob and Woochan Jang Retinal Stem Cells Ani V. Das, Jackson James, Sreekumaran Edakkot, and Iqbal Ahmed Transdifferentiation in the Nervous System Ying Liu and Mahendra S. Rao Neural Progenitor Cells of the Adult Human Brain Steven A. Goldman ES Cells and Neurogenesis Robin L. Wesselschmidt and John W. McDondald Mobilizing of Neural Precursers in the Adult Central Nervous System Theo D. Palmer and Fred H. Gage Neural Stem Cells and Transplant Therapy: Intrinsic Programs and Clinical Applications Jaime Imitola and Evan Y. Snyder Appendix A: Neural Stem Cell Companies Appendix B: Stem Cells and Transplants Appendix C: Patents and Stem Cells Appendix D: Stem Cells and US Federal Guidelines