This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine.

Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus.

This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.

Gives a state-of-the-art overview on macrophage functions Covers various aspects of macrophage development and formation Discusses possible roles of macrophages in disease and cancer Includes supplementary material: sn.pub/extras

Autorentext
Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University of Texas, M D AndersonCancer Center.

Inhalt
Part A. Evolution, origin and fate of macrophages.- 1 Evolutionary aspects of Macrophages polarization.- 2 Development and functional differentiation of tissue-resident vs. monocyte-derived macrophages in inflammatory reactions.- 3 Hofbauer cells placental macrophages of fetal origin.- 4 Mesenchymal stem cells direct the immunological fate of macrophages.- 5 Monocyte/Macrophage - NK cell Cooperation: Old Tools for New Functions.- 6 Macrophages in non-vertebrates: from insects and crustaceans to marine bivalves.- Part B. Immunobiology of macrophages.- 7 F4/80 as a Major Macrophage Marker: The case of the Peritoneum and Spleen.- 8 Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase.- 9 Role for mechanotransduction in macrophage and dendritic cell immunobiology.- Part C. Role of macrophages in disease.- 10 Macrophages' Role in Tissue Disease and Regeneration.- 11 Macrophages and their contribution to the development of atherosclerosis.- 12 Macrophage Dysfunction in Respiratory Disease.- Part D. Macrophages as a target for biointervention.- 13 Activation of macrophages in response to biomaterials.- 14 Macrophage differentiation in normal and accelerated wound healing.- 15 Macrophages and RhoA pathway in transplanted organs.