This volume constitutes the refereed proceedings of 10th International Conference on Machine Learning and Soft Computing, ICMLSC 2026, held in Osaka, Japan during February 46, 2026.

The 54 full papers included in thisbook were carefully reviewed and selected from 132 submissions. They were organized in topical sections as follows: Machine Learning Theory and Intelligent Computing in Multi scenario Applications; Key Technologies of Perception based Computer Vision and Digital Image Processing; Intelligent Information Processing and Decision Optimization Empowered by Artificial Intelligence Technology; Network and Information Security Protection Strategy; Design of Intelligent Systems and Robust Control Methods.