The therapeutic era for MS has begun, and many new, potentially effective treatments are now available. MRI offers a range of techniques which are more reliable and sensitive than any other available approach in detecting brain and spinal cord abnormalities, monitoring their evolution, and providing in vivo information about heterogenous pathological substrates of the MS lesions. Readers will find this volume a valuable summary of the state-of- the art, as well as a useful reference text from which to plan future clinical trials in MS.

Inhalt

Clinical and Paraclinical Outcomes for Treatment Trials in Multiple Sclerosis The Use of Magnetic Resonance Imaging to Select Patients for MS Clinical Trials The Application of MRI to Phase II Trials in Multiple Sclerosis MR Techniques to Monitor Phase III Treatment Trials New Strategies to Increase MRI Sensivity in Detecting Individual MS Lesions and Short-term Disease Activity: Perspectives for Future Clinical Trials Problems with Conventional MRI and New Strategies to Improve the Utility of MR in Future Clinical Trials Review of the Results of Previous Phase II, MRI-monitored clinical trials Magnetic Resonance Techniques in Phase III: Clinical Trials in Multiple Sclerosis Standardization, Optimisation and Organisation of MRI for Monitoring Clinical Trials Statistical Approaches to the Use of MRI Data for Clinical Trials