Angiogenesis is a multistep process, which involves activation, proliferation and directed migration of endothelial cells to form new capillaries from existing vessels. Under physiological conditions, in the adult organisms angiogenesis is extremely slow, yet it can be activated for a limited time only in situations such as ovulation or wound healing. In a number of disease states, however, there is a derangement of angiogenesis, which can contribute to the pathology of these conditions. Hence, understanding the molecular biology of endothelial cell activation and differentiation and the mechanisms involved in the regulation of angiogenesis, could explain the derangement in disease states and also provide the basis for developing promoters or suppressors of angiogenesis for clinical applications. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis: Molecular Biology, Oinical Aspects" held in Rhodes, Greece, from June 16-27, 1993. This meeting was a comprehensive review of the various aspects of angiogenesis such as embryonic development, endothelial cell heterogeneity and tissue specificity, molecular biology of endothelial cell, mechanisms for the regulation of angiogenesis, disease states in which angiogenesis is involved and potential application of promoters or suppressors of angiogenesis. The presentations and discussions of the meeting provided an opportunity for investigators from many different areas of basic science and medicine to exchange information, evaluate the present status and provide future research directions in the field of angiogenesis.

Zusammenfassung
Proceedings of a NATO ASI held in Rhodes, Greece, June 16-27, 1993

Inhalt
Embryonic Development and Angiogenesis.- Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage?.- Cellular and Molecular Biology of Endothelial Cell Differentiation during Embyronic Development.- Endothelial Cell Heterogeneity and Organ Specificity.- Molecular Biology of Angiogenesis.- Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis.- Human Basic Fibroblast Growth Factor: Structure-Function Relationship of an Angiogenic Molecule.- Angiogenesis Models Identify Factors which Regulate Endothelial Cell Differentiation.- EMA-1, a Novel Endothelial Cell Surface Molecule That Is Preferentially Expressed by Migrating Endothelial Cells.- Early Response Genes in Endothelial Cells.- P1GF: Placenta Derived Growth Factor.- Expression of the M-Subunit of Laminin Correlates with Increased Cell Adhesion and Metastatic Propensity.- The Proliferative Effect of Substance P on Capillary Endothelial Cells Is Mediated by Nitric Oxide.- Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor.- Interactions between Oxidized Lipoprotein(a) [Lp(a)] Monocytes and Endothelial Cells.- Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins.- A Novel Laminin Domain Involved in Adhesion of Endothelial Cells.- Regulation of Angiogenesis.- Regulation of Angiogenesis: The Role of Protein Kinase, Nitric Oxide, Thrombin and Basement Membrane Synthesis.- Basement Membrane Laminin-Derived Peptide SIKVAV Promotes Angiogenesis and Tumor Growth.- Release of Gangliosides in the Microenvironment and Angiogenic Response in Vivo.- Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis.- Endothelial Plasminogen Activators andMatrix Metalloproteinases in Fibrinolysis and Local Proteolysis.- Angiogenesis and Disease States.- Tumor Antiangiogenesis: Which Way?.- Therapeutic Angiogenesis in Surgery and Oncology.- Endothelial Cell Stimulating Angiogenesis Factors in Relation to Disease Processes.- Hyaluronan and Angiogenesis: Molecular Mechanisms and Clinical Applications.- Chronic Cellular Injury and Human Proliferative Disorders.- Cellular and Molecular Mechanisms of Angiogenesis in the Brain.- Angiogenesis and Fibrin Degradation in Human Breast Cancer.- Thrombin-Mediated Events Implicated in Post-Thrombotic Recovery.- Anti-Tumor Effects of GBS Toxin Are Caused by Induction of a Targeted Inflammatory Reaction.- Biological Data and Docking Experiments of bFGF Sulfonated Distamycin A Derivative Complex.- Clinical Ocular Angiogenesis.- Methodology.- In Vivo Assays for Angiogenesis.- Quantitative Analysis of Extracellular Matrix Formation in Vivo and in Vitro.- Microvascular Morphometry.- The Corneal Model for the Study of Angiogenesis.- Factitious Angiogenesis: Not So Factitious Anymore? The Role of Angiogenic Processes in the Endothelialization of Artificial Cardiovascular Prostheses.- Abstracts.- Participants.