Authored by an international team of experts in the field Describes and discusses recent major diabetes and lipid related clinical trials Offers a comprehensive overview, including clinical, laboratory and basic science elements

Autorentext

Alicia J. Jenkins, MBBS, MD, FRACP, FRCP

NHMRC Clinical Trials Centre, University of Sydney

Medical Foundation Building Level 6

92-94 Parramatta Rd

Camperdown, Sydney, 2050, NSW, Australia

alicia.jenkins@sydney.edu.au

Peter P. Toth, MD, PhD, FCCP, FESC, FAHA, FACC

Department of Medicine, Division of Cardiology

Johns Hopkins University School of Medicine

Baltimore, Maryland

USA

Peter.toth@cghmc.com

Alicia J. Jenkins, MBBS, MD, FRACP, FRCP is an endocrinologist and researcher. She is a Professor of Diabetes and Vascular Medicine at the University of Sydney, Australia and has honorary academic appointments at Universities in the USA, UK and Hong Kong. Her higher research degree and ongoing clinical and research relates to lipoproteins in diabetes, (clinical, biochemical and molecular) biomarkers, and to the prediction and prevention of the complications of diabetes. She and her research team and collaborators undertake clinical and basic research and clinical trials related to diabetes and its complications and to cardiovascular disease. She is a Chief Investigator on several investigator initiated clinical trials in diabetes, including several related to lipid drugs. She has over 400 publications, cited over 10,000 times and an H-index of 53. Alicia has previously worked with Peter Toth to edit the first edition of Lipoproteins in Diabetes Mellitus. Alicia works clinically in Type 1 diabetes clinics and is currently on the International Diabetes Federation Western Pacific Region Executive Council, co-Director of the Australian Cardiovascular Alliance Precision Medicine Flagship, the Lipid Guidelines Committee for the Australian Diabetes Society and President of the diabetes aid organisation Insulin For Life.

Peter P. Toth, MD, PhD is director of preventive cardiology at the CGH Medical Center in Sterling, Illinois. He is Professor of Clinical Family and Community Medicine at the University of Illinois School of Medicine, Professor of Clinical Medicine at Michigan State University College of Osteopathic Medicine, and Adjunct Associate Professor of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine. Dr. Toth is a past president of the National Lipid Association and American Board of Clinical Lipidology. He is President of the American Society of Preventive Cardiology. Dr. Toth has authored and coauthored over 500 publications in medical and scientific journals and textbooks. He is Series Editor of Springer's textbook collection in Contemporary Cardiology. He has edited and written 19 textbooks on various aspects of cardiovascular medicine. He has lectured on many topics in cardiovascular medicine throughout the world. His Google Scholar score include 13,125 citations, h-index 58, and i10-index 224.

Inhalt

Part 1 : Lipoprotein Metabolism, Qualitative Changes and Measurements .- 1. Laboratory Assessment of Lipoproteins in Type 2 Diabetes.- 2. Tools for Assessing Lipoprotein Metabolism in Diabetes Mellitus.- 3. Links Between Glucose and Lipoproteins.- 4. Apoproteins and Cell Surface Receptors Regulating Lipoprotein Metabolism in the Setting of Type 2 Diabetes.- 5. Lipoprotein metabolism and alterations induced by insulin resistance and diabetes.- 6. The PPAR system in diabetes.- 7. Production And Metabolism Of Triglyceride-Rich Lipoproteins: Impact Of Diabetes.- 8. Triglyceride- And Cholesterol-Rich Remnant Lipoproteins In Risk Of Cardiovascular Disease In Diabetes Mellitus.- 9. HDL Function In Diabetes.- 10. Lipoprotein (a): Metabolism, Pathophysiology and Impact on Diabetes Mellitus.- 11. Lipoprotein Glycation in Diabetes Mellitus.- 12. Lipid:Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes.- Part 2 : Lipoproteins and the Complications of Diabetes .- 13. The Role of Modified Forms of LDL and Corresponding Autoantibodies in the Development of Complications in Diabetes.- 14. Endothelial dysfunction in type 2 diabetes, with an update on new interventions.- 15. Lipoproteins and diabetic kidney disease.- 16. Lipids and Diabetic Retinopathy.- 17. Roles of Extravasated and Modified Plasma Lipoproteins in Diabetic Retinopathy.- 18. The Role Of Lipids And Lipoproteins In Peripheral Neuropathy.- 19. Lipoproteins and Ischemic Stroke in Diabetes.- Part 3 : Lipoprotein Treatment in Diabetes .- 20. About Randomized Clinical Trials Related to Lipoproteins in Diabetes Mellitus.- 21. Effects of Lifestyle (Diet, Plant Sterols, Exercise and Smoking) and Glycemic Control on Lipoproteins in Diabetes.- 22. Statin Therapy: Impact on Dyslipidemia and Cardiovascular Events in Patients with Diabetes.- 23. Statin intolerance An overview for clinicians.- 24. Fibrate Therapy: Impact on Dyslipidemia and Cardiovascular Events in Patients with Diabetes Mellitus Type 2.- 25. EPA and Mixed Omega-3 Fatty Acids: Impact on Dyslipidemia and Cardiovascular Events in Patients With Diabetes.- 26. Cholesterol Absorption Inhibitors (Ezetimibe) and Bile Acid Binding Resins (Colesevelam HCl) as Therapy for Dyslipidemia in Patients with Diabetes Mellitus.- 27. Clinical Efficacy Of Proprotein Convertase Synthase Kexin Type 9 Inhibition In Persons With Diabetes Mellitus.- 28. Clinical Care of Lipids in People with Type 1 diabetes.- 29. Adjunct drug treatment to reduce vascular disease in people with diabetes.- 30. Emerging lipoprotein-related therapeutics for patients with diabetes.- Part 4 : Epidemiology of Diabetes and Diabetic Dyslipidemia .- 31. Diabetes Epidemiology And Its Implications.- 32. Epidemiology, Control, and Cardiovascular Outcomes of Dyslipidemia in Diabetes.