Klappentext

1. The Role of Heat Shock Proteins in the Regulation of Steroid Receptor Function.- 2. Subcellular and Subnuclear Trafficking of Steroid Receptors.- 3. Structure and Function of the Steroid and Nuclear Receptor Ligand-Binding Domain.- 4. Structure and Function of the Steroid and Nuclear Receptor DNA Binding Domain.- 5. Modulation of Steroid/Nuclear Receptor Dimerization and DNA Binding by Ligands.- 6. Molecular Mechanisms of Nuclear-Receptor-Mediated Transcriptional Activation and Basal Repression.- 7. Transcriptional Cross-Talk by Steroid Hormone Receptors.- 8. Chromatin and Steroid-Receptor-Mediated Transcription.- 9. Regulation of Glucocorticoid and Estrogen Receptor Activity by Phosphorylation.- 10. Monomeric Nuclear Receptors.- 11. Orphan Nuclear Receptors and Their Ligands.

   Zusammenfassung
   This text presents the topic of endocrinology viewed from the perspective of molecular biology.

   Inhalt

   The role of heat shock proteins in the regulation of steroid nuclear receptor function, Didier Picard; regulation of nuclear localization of steroid and nuclear receptors, Donald B. DeFranco; Structure and function of the steroid and nuclear receptor ligand-binding domain, S. Stoney Simmons, Jr. Structure and function of the steroid and nuclear receptor DNA-binding domain, Fraydoon Rastinejad; Modulation of nuclear receptors dimerization - cross-talk with RXR, Boris Cheskis, Leonard Freedman; Molecular mechanisms of nuclear receptor-mediated transcriptional activation and basal repression, Milan Bagchi; Receptor-mediated repression of activated transcription, Peter Herrlich, Martin Gottlicher; Chromatin and receptor-mediated transcription, Catherine E. Watson, Trevor Archer; Regulation of receptor activity by phosphorylation, Michael Garabedian et al; Mononumeric nuclear receptors, Mitchell A. Lazar, Heather P. Hardling; Orphan receptors and ligands, Barry Marc Forman.