The book brings together recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. Contents (sections) : Individual Variation of Radio- and Chemosensitivity, Neurotoxicity, Skin and Mucosal Toxicity, Lung Toxicity, Cardiotoxicity, Nephrotoxicity, Gonodal Toxicity, Disturbance of Skeletal Growth, Cancerogenesis.

Inhalt
1 Individual Variation of Radio- and Chemosensitivity.- 1.1 Impact of Endogenous and Exogenous Factors on Radiation Sequelae.- 1.2 Endogenous and Exogenous Factors Modifying Chemosensitivity to Cytostatic Drugs.- 2 Neurotoxicity.- 2.1 Radiation-Induced Injury of the Central Nervous System.- 2.2 Cytostatic-Induced Central Nervous System Abnormalities.- 2.3 Radiation Myelopathy.- 2.4 Acute and Late Toxicity on Peripheral Nerves After Radiotherapy.- 2.5 Acute and Late Toxicity on Peripheral Nerves After Chemotherapy A Review.- 2.6 Endocrine Dysfunction After Brain Tumor Therapy in Children.- 2.7 Endocrine Dysfunction in Adults After Radiotherapy for Pituitary Adenomas and Suprasellar Tumors.- 2.8 Late Sequelae Affecting the Ear.- 2.9 Ototoxicity in Pediatric Oncology.- 3 Skin and Mucosal Toxicity.- 3.1 Biological Basis for Skin and Mucosal Toxicity.- 3.2 Radiation-Induced Fibrosis: Experimental Studies.- 3.3 Lymphedema of the Arm After Treatment of Breast Cancer.- 3.4 Skin and Mucosal Damage After Radiotherapy for Head and Neck Tumors.- 3.5 Mucosal Toxicity After Radiochemotherapy.- 3.6 Complications of the Small Intestine and the Pancreas After Intraoperative Radiotherapy.- 3.7 Skin Toxicity.- 4 Lung Toxicity.- 4.1 Radiation Pneumopathy Experimental and Clinical Data.- 4.2 Lung Toxicity of Chemotherapeutic Agents.- 4.3 Differential Diagnosis of Treatment Sequelae in the Lung.- 5 Cardiotoxicity.- 5.1 Evaluation of Late Cardiotoxicity by Pulsed Doppler Echocardiography in Patients Treated for Hodgkin's Disease.- 5.2 Anthracycline-Induced Cardiotoxicity in Children: Pathophysiology and Prevention.- 5.3 Radiation-Induced Cardiotoxicity: Experimental Data.- 5.4 Cardiotoxicity After Megavoltage Irradiation and Chemotherapy for Hodgkin's Disease with Special Emphasison Coronary Heart Disease Mortality The Freiburg Experience 1940-1992.- 5.5 Cardiac Morbidity and Mortality Followig Radiotherapy.- 6 Nephrotoxicity.- 6.1 Nephrotoxicity of Ifosfamide in Children.- 6.2 Radiation Nephritis.- 7 Gonadal Toxicity.- 7.1 Long-Term Gonadal Dysfunction and Its Impact on Bone Mineralization in Patients Following COPP/ABVD Chemotherapy for Hodgkin's Disease.- 7.2 Gonadal Dysfunction After Radiotherapy.- 8 Disturbances of Sceletal Growth.- 8.1 Dose-Time Considerations for Skeletal Growth Disturbances After Radiotherapy.- 8.2 Disturbances in Growth of Bone, Muscle, and Fat Tissue Following Irradiation in Childhood.- 8.3 Growth Failure Secondary to Radiotherapy of Brain Tumors in Childhood.- 9 Cancerogenesis.- 9.1 Experiments on the Carcinogenic Potential of Antineoplastic Agents.- 9.2 Secondary Malignancies Following Cytotoxic Chemotherapy.- 9.3 Secondary Malignancies After Radiotherapy.- List of Contributors.