Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics could be useful in the treatment of diseases of the central nervous system. This book provides an overview of the role and neuropharmaceutical potential of these peptides, and discusses the state of the art and future trends in the use of peptide pharmacotherapy involving the brain.

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From the contents:

Fleur L. Strand: Neuropeptides: general characteristics and neuropharmaceutical potential in treating CNS disorders.- David J. Begley and Milton W. Brightman: Structural and functional aspects of the blood-brain barrier.- Abba J. Kastin and Weihong Pan: Peptide transport across the blood-brain barrier.- Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases.- David Fortin: Altering the properties of the blood-brain barrier: disruption and permeabilization.- Katalin Prokai-Tatrai and Laszlo Prokai: Modifying peptide properties by prodrug design for enhanced transport into the CNS.- Suresh P. Vyas: CNS-delivery via conjugation to biological carriers: physiological-based approaches.- Jamal Temsamani and Jean-Michel Scherrmann: Peptide vectors as drug carriers. Index Vol. 61.