Lamins in Genome Organization and Diseases

This new book covers the molecular biology of lamins, which are nuclear-derived intermediate filament proteins that play diverse roles in nuclear homeostasis, such as conferring structural rigidity to the nucleus and holding chromosomes together. Numerous mutations in the lamin type A protein give rise to a plethora of diseases called laminopathies affecting muscle, cardiac, adipose, and nervous tissues, and to a combination of all of them in the form of progeroid syndromes. Furthermore, the differential expression of lamins has been implicated in a wide variety of cancers. Over the past two decades, there has been an increasing number of interesting findings related to the perturbation of signalling cascades and transcriptome analysis in the pathogenesis of laminopathies. Few reports have also shed light on the epigenetic changes associated with these diseases. The rapid advancement of chromosome conformation capture methods has provided a new impetus to delineate the finer details of chromosome association with lamins at the topological level. Bringing together most of these exciting findings in a book that appeals to a broad readership of lamins and chromatin biology.

Explores in-depth lamina biology, disease mechanisms, and nuclear functions in health and disease Highlights new research on lamins in cancer, linking mutations to tumor progression and gene regulation in epigenetics Integrates lamin and chromatin biology, focusing on recent discoveries to advance molecular medicine and treatments

Autorentext

Kaushik Sengupta , PhD, Dr. Kaushik Sengupta holds a Doctor of Philosophy from Max Planck Institute for Biophysics/ Goethe University Frankfurt, Germany followed by a postdoctoral research experience at the Northwestern University, Chicago in Cell & Molecular Biology. He is a Professor in the Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India. Dr. Kaushik Sengupta is a researcher in molecular biophysics who has pioneered several new approaches to the study of lamin proteins. Lamin proteins are a central component of cellular and nuclear architecture, and lamin mutations have recently been shown to cause a plethora of diseases. Dr. Sengupta has contributed significantly to the understanding of lamin proteins and their mutations and the pathophysiological pathways leading to the diseases. As such, his work is of immense significance to the field and global community, because it is actively driving new research on lamins in molecular biophysics and leading progress in the knowledge, diagnosis, and treatment of medical disorders associated with lamin proteins and mutations. Dr. Sengupta has 1896 citations with an i10 index of 18. Thus, Dr. Sengupta's publication record places him among the most impactful researchers in molecular biophysics today.

Antoine Muchir , PhD, Dr. Antoine Muchir obtained his Doctor of Philosophy from the University of Paris, France followed by research careers at the Columbia University, USA and Santhera Pharmaceuticals. Dr. Muchir is currently the team leader of the Signaling Pathways & Striated Muscles Group at the Institute of Myology in France. He is one of the world's leading experts on the molecular mechanisms that cause cardiac dysfunction as well as disease-causing mutations in LMNA gene encoding nuclear lamin A. His works on laminopathies are widely cited globally which makes him one of the most impactful scientists in the community. Dr. Muchir has 5800 citations with an i10 index of 56.

Inhalt

Chapter 1. Role of Nuclear Lamins in the Regulation of the Genome: Focus on Cardiolaminopathy.- Chapter 2. Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei.- Chapter 3. Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.- Chapter 4. Laminopathies and Cancers- Involvement of Lamins and Lamin-Chromatin Interactions.- Chapter 5. Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis- tous pour un et un pour tous.- Chapter 6. Changes in Chromatin Organization and Mechanotransduction Mediated by Mutant Lamins in Laminopathies.- Chapter 7. ECM-Lamin Crosstalk in the Regulation of Genomic Stability.- Chapter 8. The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation?.- Chapter 9. The Role of Lamins in Genome Organization: A Modelling Perspective.- Chapter 10. The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies.- Chapter 11. Dynamic Post-Translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology.