Surgical Versus Conservative Treatment of Intracranial Arteriovenous Malformations

The main aim of this study is to define the clinical criteria which must be considered in order to come to an adequate decision whether a patient with intracranial arteriovenous malformation (AVM) should be operated upon or treated conservatively. A special method was used to reduce the effects of selection. This method made it possible to evaluate the therapeutic efficacy of conservative treatment versus surgery. The method implies that patients with equal combinations of variables (risk profiles) were compared in the two treatment lines. The variables building up the risk-profile pattern were chosen by analysing the decision process, as it was originally practiced by the surgeon who selected and treated the patients of this study. The risk profiles thus described relevant characteristics of the patient and his malformation. The variables were assigned numerical values accord ing to their prognostic value. Summation of the variables making up the risk profile then gives each risk profile a certain value. A low value symbolizes a bad prognosis and a high value a good prognosis in both treatment groups. There were many risk profiles with the same value in both groups and a comparison could be made over a large part of the risk-profile scale. This comparison showed that surgical treatment of A VM can always be justified, although the indications for surgery are less strong in patients with low risk profile values.

Inhalt
I. General Introduction.- Aim of the Study.- Methodological Considerations.- II. Morphological Aspects.- Classification.- Patients and Methods.- Results.- Discussion.- III. The Original Clinical Decision.- Patients and Methods.- Results.- Discussion.- IV. Conservative Treatment.- Previous Reports.- Patients and Methods.- Results.- Discussion.- V. Surgical Treatment.- Previous Reports.- Patients and Methods.- Results.- Discussion.- VI. The Decision Process and Assessment of the Prognosis.- Patients and Methods.- Methods of Calculation.- Results.- Discussion.- VII. General Discussion and Conclusion.- References.