Following the monographs by STRAUB (1924) and LENDLE (1935), this is the third contribution to the "Pharmacology of Cardiac Glycosides" within the Handbook of Experimental Pharmacology, which was founded by ARTHUR HEFFTER and con tinued by WOLFGANG HEUBNER. Because of the need created by the length of time that had elapsed since LENDLE'S work, the editorial board requested the rapid ap pearance of this 56th volume, which represents current knowledge of the pharma cology and clinical pharmacology of cardiac glycosides. In order to avoid any delay, numerous authors were invited to contribute because shorter contributions take less time to prepare and are consequently more up-to-date. The disadvantage is that some overlap between certain chapters could not be avoided, despite the editor's efforts. Overlapping can, however, actually be useful, in that differing opinions may be provided and topical issues discussed from varying viewpoints. This re minds the reader that scientific horizons in medicine should often be widened or revised. I would like to thank DR. ALANNA Fox and DR. K. ANANTHARAMAN for their help and advice in the revision of certain chapters. I am also grateful to Springer Verlag, and particularly to MR. WINSTANLEY and MR. EMERSON, for their contribu tion to the completion of this volume through translation and corrections. In con clusion I would like to thank MRS. WALKER, MR. BISCHOFF, MRS. SEEKER, and MR. BERGSTEDT of Springer-Verlag for their helpful support.

Klappentext

With contributions by numerous experts

Inhalt
1 Introduction and Remarks on the History of Cardiac Glycosides.- 2 Chemistry and Structure-Activity Relationships of Cardioactive Steroids.- A. Introduction.- B. Structure-Activity Relationships.- C. Influence of Additional Structural Modifications.- D. Summary.- References.- Methods for the Determination of Cardiac Glycosides.- 3 Chemical and Chromatographic Methods.- 4 Use of Radioactively Labeled Glycosides.- 5 Radioimmunologic Methods.- 6 ATPase for the Determination of Cardiac Glycosides.- 7 Rubidium Uptake in Erythrocytes.- Biological Methods for the Evaluation of Cardiac Glycosides.- 8 Evaluation of Cardiac Glycosides in the Intact Animal.- 9 The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioactive Steroids.- 10 Evaluation of Cardiac Glycosides in Isolated Heart Preparations Other than Papillary Muscle.- Mode of Action of Cardiac Glycosides.- 11 The Positive Inotropic Action of Cardiac Glycosides on Cardiac Ventricular Muscle.- 12 Influence of Cardiac Glycosides on Electrophysiologic Processes.- 13 Influence of Cardiac Glycosides on Myocardial Energy Metabolism.- 14 Effects of Cardiac Glycosides on Na+, K+-ATPase.- 15 Influence of Cardiac Glycosides on their Receptor.- 16 Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosides.- 17 Influence of Cardiac Glycosides on Cell Membrane.- 18 Influence of Cardiac Glycosides on Electrolyte Exchange and Content in Cardiac Muscle Cells.- 19 Effects of Cardiac Glycosides on Myofibrils.- 20 Substances Possessing Inotropic Properties Similar to Cardiac Glycosides.- Non-Cardiac Effects of Cardiac Glycosides.- 21 Effects of Cardiac Glycosides on Central Nervous System.- 22 Effects of Cardiac Glycosides on Vascular System.- 23 Effects of Cardiac Glycosides on SkeletalMuscle.- 24 Effects of Cardiac Glycosides on Autonomic Nervous System and Endocrine Glands.- 25 Effects of Cardiac Glycosides on Kidneys.- Author Index.